Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tymptm1Mihi mutation
(0 available);
any
Tymp mutation
(37 available)
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tymptm1Mihi mutation
(0 available);
any
Tymp mutation
(37 available)
Upp1tm1Gp mutation
(2 available);
any
Upp1 mutation
(66 available)
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nervous system
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• brain white matter contains multiple vacuoles in the subcortical, periventricular, internal capsule and cerebellar white matter unlike in wild-type mice
• vacuoles are larger and more abundant in the cerebellum
• at 22 months, mice exhibit an increase in T2 signal on an MRI in the cerebral white matter, an indication of leukoencephalopathy
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• older mice exhibit vacuoles in the basal ganglia unlike in wild-type mice
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• older mice exhibit vacuoles in the dentate nuclei unlike in wild-type mice
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• brain white matter contains multiple vacuoles in the subcortical, periventricular, internal capsule and cerebellar white matter unlike in wild-type mice
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cellular
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• mitochondrial DNA in the brain is reduced 27% compared to in wild-type mice
• depletion of mtDNA is more severe in older mice
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• the mitochondrial respiratory chain is deficient in the brain with 30% less complex I and IV activities compared to in wild-type mice
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homeostasis/metabolism
skeleton