Phenotypes associated with this allele

• Allele Symbol: Ffar3^tm1Reh
• Allele Name: targeted mutation 1, Robert E Hammer
• Allele ID: MGI:3829251
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ffar3^tm1Reh/Ffar3^tm1Reh	involves: 129S6/SvEvTac * C57BL/6J	MGI:3829260

Genotype
MGI:3829260

hm1

• Allelic Composition: Ffar3^tm1Reh/Ffar3^tm1Reh
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal digestion ( J:143567 )

• when fed a polysaccharide-rich and low-fat diet, germ-free mice cocolonized with B. thetaiotaiomicron (Bt) and M. smithii (Ms) exhibit higher cecal glucan levels than similarly treated wild-type mice

abnormal feces composition ( J:143567 )

• the amount of short chain fatty acids in the feces is increased in germ-free mice cocolonized with B. thetaiotaiomicron (Bt) and M. smithii (Ms) fed a polysaccharide-rich and low-fat diet compared to similarly treated wild-type mice

• however, fecal triglyceride and free fatty acid content of germ-free mice cocolonized with Bt and Ms fed a polysaccharide-rich and low-fat diet is normal

abnormal intestinal transit time ( J:143567 )

• intestinal transit rate of germ-free mice cocolonized with B. thetaiotaiomicron (Bt) and M. smithii (Ms) fed a polysaccharide-rich and low-fat diet is faster than in similarly treated wild-type mice

• however, germ-free mice exhibit normal transit rates

liver/biliary system

decreased liver triglyceride level ( J:143567 )

• when fed a polysaccharide-rich and low-fat diet, germ-free mice cocolonized with B. thetaiotaiomicron (Bt) and M. smithii (Ms) fail to exhibit an increase in hepatic triglyceride levels that is observed in similarly treated wild-type mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:143567 )

N • despite weight loss, germ-free mice cocolonized with B. thetaiotaiomicron (Bt) and M. smithii (Ms) or conventionally raised mice fed a polysaccharide-rich and low-fat diet exhibit normal body temperature

decreased circulating leptin level ( J:143567 )

• when fed a polysaccharide-rich and low-fat diet, germ-free mice cocolonized with B. thetaiotaiomicron (Bt) and M. smithii (Ms) or conventionally raised mice exhibit reduced leptin serum levels compared to in similarly treated wild-type mice

abnormal energy homeostasis ( J:143567 )

• when fed a polysaccharide-rich and low-fat diet, germ-free mice cocolonized with B. thetaiotaiomicron (Bt) and M. smithii (Ms) exhibit reduced caloric extraction compared to similarly treated wild-type mice

decreased liver triglyceride level ( J:143567 )

• when fed a polysaccharide-rich and low-fat diet, germ-free mice cocolonized with B. thetaiotaiomicron (Bt) and M. smithii (Ms) fail to exhibit an increase in hepatic triglyceride levels that is observed in similarly treated wild-type mice

adipose tissue

decreased epididymal fat pad weight ( J:143567 )

• when fed a polysaccharide-rich and low-fat diet, the weight of epididymal fat pads from germ-free mice cocolonized B. thetaiotaiomicron (Bt) and M. smithii (Ms) or conventionally raised mice is lower than in similarly treated wild-type mice

growth/size/body

decreased body weight ( J:143567 )

• when fed a polysaccharide-rich and low-fat diet, germ-free mice cocolonized with B. thetaiotaiomicron (Bt) and M. smithii (Ms) or conventionally raised mice exhibit reduced daily weight gain and weight after 28 days compared to similarly treated wild-type mice

behavior/neurological

behavior/neurological phenotype ( J:143567 )

N • despite weight loss, germ-free mice cocolonized with B. thetaiotaiomicron (Bt) and M. smithii (Ms) or conventionally raised mice fed a polysaccharide-rich and low-fat diet exhibit normal food intake and activity levels