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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Dspp-TGFB1)3Kul
transgene insertion 3, Ashok B Kulkarni
MGI:3828146
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Dspp-TGFB1)3Kul/? FVB/N-Tg(Dspp-TGFB1)3Kul MGI:3835822
tg2
Tg(Dspp-TGFB1)3Kul/? involves: FVB/N MGI:3835811


Genotype
MGI:3835822
tg1
Allelic
Composition
Tg(Dspp-TGFB1)3Kul/?
Genetic
Background
FVB/N-Tg(Dspp-TGFB1)3Kul
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype

Gross tooth abnormalities in Tg(Dspp-TGFB1)3Kul/? mice

skeleton
• mineralization of the incisors is reduced by about 90% compared to controls based on X-ray analysis
• molar mineralization is reduced by 62%
• calcium mineralization is unevenly distributed throughout the dentin and enamel
• incisors have a highly disorganized odontoblast layer and irregular dentinal tubules all along the dentinal layer
• teeth turn chalky-white and then fracture starting around 2 weeks of age

craniofacial
• mineralization of the incisors is reduced by about 90% compared to controls based on X-ray analysis
• molar mineralization is reduced by 62%
• calcium mineralization is unevenly distributed throughout the dentin and enamel
• incisors have a highly disorganized odontoblast layer and irregular dentinal tubules all along the dentinal layer
• teeth turn chalky-white and then fracture starting around 2 weeks of age

growth/size/body
• mineralization of the incisors is reduced by about 90% compared to controls based on X-ray analysis
• molar mineralization is reduced by 62%
• calcium mineralization is unevenly distributed throughout the dentin and enamel
• incisors have a highly disorganized odontoblast layer and irregular dentinal tubules all along the dentinal layer
• teeth turn chalky-white and then fracture starting around 2 weeks of age




Genotype
MGI:3835811
tg2
Allelic
Composition
Tg(Dspp-TGFB1)3Kul/?
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• ameloblasts appear normal until the presecretory stage when they began to detach from the dentin surface
• in incisors of 2 day old mice, ameloblasts detach from the labial dentin surface of the teeth, secrete bubble-like masses, and form cysts without the formation of a Tomes' process
• ameoblasts adjacent these cysts fail to properly mature
• ameoblasts also detach from the dentin of the first and second molars starting at postnatal day 7
• dentin is disorganized and fractured around the root of incisors in 30 day old mice
• dentin is also abnormally mineralized
• odontoblasts are sometimes trapped in the dentin resulting in an osteodentin phenotype
• the very thin enamel of young mice is quickly lost through attrition or fracturing
• most mice initially have very thin enamel on their teeth before losing it
• the enamel of incisors from 7 day old mice is aprismatic and amorphous
• the enamel of molars has a pitted appearance
• enamel lacks the rod-like that help characterize the enamel-dentin junction

craniofacial
• ameloblasts appear normal until the presecretory stage when they began to detach from the dentin surface
• in incisors of 2 day old mice, ameloblasts detach from the labial dentin surface of the teeth, secrete bubble-like masses, and form cysts without the formation of a Tomes' process
• ameoblasts adjacent these cysts fail to properly mature
• ameoblasts also detach from the dentin of the first and second molars starting at postnatal day 7
• dentin is disorganized and fractured around the root of incisors in 30 day old mice
• dentin is also abnormally mineralized
• odontoblasts are sometimes trapped in the dentin resulting in an osteodentin phenotype
• the very thin enamel of young mice is quickly lost through attrition or fracturing
• most mice initially have very thin enamel on their teeth before losing it
• the enamel of incisors from 7 day old mice is aprismatic and amorphous
• the enamel of molars has a pitted appearance
• enamel lacks the rod-like that help characterize the enamel-dentin junction

growth/size/body
• ameloblasts appear normal until the presecretory stage when they began to detach from the dentin surface
• in incisors of 2 day old mice, ameloblasts detach from the labial dentin surface of the teeth, secrete bubble-like masses, and form cysts without the formation of a Tomes' process
• ameoblasts adjacent these cysts fail to properly mature
• ameoblasts also detach from the dentin of the first and second molars starting at postnatal day 7
• dentin is disorganized and fractured around the root of incisors in 30 day old mice
• dentin is also abnormally mineralized
• odontoblasts are sometimes trapped in the dentin resulting in an osteodentin phenotype
• the very thin enamel of young mice is quickly lost through attrition or fracturing
• most mice initially have very thin enamel on their teeth before losing it
• the enamel of incisors from 7 day old mice is aprismatic and amorphous
• the enamel of molars has a pitted appearance
• enamel lacks the rod-like that help characterize the enamel-dentin junction





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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory