• mineralization of the incisors is reduced by about 90% compared to controls based on X-ray analysis

• molar mineralization is reduced by 62%

• calcium mineralization is unevenly distributed throughout the dentin and enamel

• incisors have a highly disorganized odontoblast layer and irregular dentinal tubules all along the dentinal layer

• teeth turn chalky-white and then fracture starting around 2 weeks of age

• ameloblasts appear normal until the presecretory stage when they began to detach from the dentin surface

• in incisors of 2 day old mice, ameloblasts detach from the labial dentin surface of the teeth, secrete bubble-like masses, and form cysts without the formation of a Tomes' process

• ameoblasts adjacent these cysts fail to properly mature

• ameoblasts also detach from the dentin of the first and second molars starting at postnatal day 7

• dentin is disorganized and fractured around the root of incisors in 30 day old mice

• dentin is also abnormally mineralized

• odontoblasts are sometimes trapped in the dentin resulting in an osteodentin phenotype

• the very thin enamel of young mice is quickly lost through attrition or fracturing

• most mice initially have very thin enamel on their teeth before losing it

• the enamel of incisors from 7 day old mice is aprismatic and amorphous

• the enamel of molars has a pitted appearance

• enamel lacks the rod-like that help characterize the enamel-dentin junction