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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Dspp-TGFB1)3Kul
transgene insertion 3, Ashok B Kulkarni
MGI:3828146
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Dspp-TGFB1)3Kul/? FVB/N-Tg(Dspp-TGFB1)3Kul MGI:3835822
tg2
Tg(Dspp-TGFB1)3Kul/? involves: FVB/N MGI:3835811


Genotype
MGI:3835822
tg1
Allelic
Composition
Tg(Dspp-TGFB1)3Kul/?
Genetic
Background
FVB/N-Tg(Dspp-TGFB1)3Kul
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Dspp-TGFB1)3Kul mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Gross tooth abnormalities in Tg(Dspp-TGFB1)3Kul/? mice

skeleton
• mineralization of the incisors is reduced by about 90% compared to controls based on X-ray analysis
• molar mineralization is reduced by 62%
• calcium mineralization is unevenly distributed throughout the dentin and enamel
• incisors have a highly disorganized odontoblast layer and irregular dentinal tubules all along the dentinal layer
• teeth turn chalky-white and then fracture starting around 2 weeks of age

craniofacial
• mineralization of the incisors is reduced by about 90% compared to controls based on X-ray analysis
• molar mineralization is reduced by 62%
• calcium mineralization is unevenly distributed throughout the dentin and enamel
• incisors have a highly disorganized odontoblast layer and irregular dentinal tubules all along the dentinal layer
• teeth turn chalky-white and then fracture starting around 2 weeks of age

growth/size/body
• mineralization of the incisors is reduced by about 90% compared to controls based on X-ray analysis
• molar mineralization is reduced by 62%
• calcium mineralization is unevenly distributed throughout the dentin and enamel
• incisors have a highly disorganized odontoblast layer and irregular dentinal tubules all along the dentinal layer
• teeth turn chalky-white and then fracture starting around 2 weeks of age




Genotype
MGI:3835811
tg2
Allelic
Composition
Tg(Dspp-TGFB1)3Kul/?
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Dspp-TGFB1)3Kul mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• ameloblasts appear normal until the presecretory stage when they began to detach from the dentin surface
• in incisors of 2 day old mice, ameloblasts detach from the labial dentin surface of the teeth, secrete bubble-like masses, and form cysts without the formation of a Tomes' process
• ameoblasts adjacent these cysts fail to properly mature
• ameoblasts also detach from the dentin of the first and second molars starting at postnatal day 7
• dentin is disorganized and fractured around the root of incisors in 30 day old mice
• dentin is also abnormally mineralized
• odontoblasts are sometimes trapped in the dentin resulting in an osteodentin phenotype
• the very thin enamel of young mice is quickly lost through attrition or fracturing
• most mice initially have very thin enamel on their teeth before losing it
• the enamel of incisors from 7 day old mice is aprismatic and amorphous
• the enamel of molars has a pitted appearance
• enamel lacks the rod-like that help characterize the enamel-dentin junction

craniofacial
• ameloblasts appear normal until the presecretory stage when they began to detach from the dentin surface
• in incisors of 2 day old mice, ameloblasts detach from the labial dentin surface of the teeth, secrete bubble-like masses, and form cysts without the formation of a Tomes' process
• ameoblasts adjacent these cysts fail to properly mature
• ameoblasts also detach from the dentin of the first and second molars starting at postnatal day 7
• dentin is disorganized and fractured around the root of incisors in 30 day old mice
• dentin is also abnormally mineralized
• odontoblasts are sometimes trapped in the dentin resulting in an osteodentin phenotype
• the very thin enamel of young mice is quickly lost through attrition or fracturing
• most mice initially have very thin enamel on their teeth before losing it
• the enamel of incisors from 7 day old mice is aprismatic and amorphous
• the enamel of molars has a pitted appearance
• enamel lacks the rod-like that help characterize the enamel-dentin junction

growth/size/body
• ameloblasts appear normal until the presecretory stage when they began to detach from the dentin surface
• in incisors of 2 day old mice, ameloblasts detach from the labial dentin surface of the teeth, secrete bubble-like masses, and form cysts without the formation of a Tomes' process
• ameoblasts adjacent these cysts fail to properly mature
• ameoblasts also detach from the dentin of the first and second molars starting at postnatal day 7
• dentin is disorganized and fractured around the root of incisors in 30 day old mice
• dentin is also abnormally mineralized
• odontoblasts are sometimes trapped in the dentin resulting in an osteodentin phenotype
• the very thin enamel of young mice is quickly lost through attrition or fracturing
• most mice initially have very thin enamel on their teeth before losing it
• the enamel of incisors from 7 day old mice is aprismatic and amorphous
• the enamel of molars has a pitted appearance
• enamel lacks the rod-like that help characterize the enamel-dentin junction





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last database update
01/10/2017
MGI 6.07
The Jackson Laboratory