Mouse Genome Informatics
tg1
    Tg(Dspp-TGFB1)3Kul/?
FVB/N-Tg(Dspp-TGFB1)3Kul
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype

Gross tooth abnormalities in Tg(Dspp-TGFB1)3Kul/? mice

craniofacial
• mineralization of the incisors is reduced by about 90% compared to controls based on X-ray analysis
• molar mineralization is reduced by 62%
• calcium mineralization is unevenly distributed throughout the dentin and enamel
• incisors have a highly disorganized odontoblast layer and irregular dentinal tubules all along the dentinal layer
• teeth turn chalky-white and then fracture starting around 2 weeks of age


Mouse Genome Informatics
tg2
    Tg(Dspp-TGFB1)3Kul/?
involves: FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
craniofacial
• ameloblasts appear normal until the presecretory stage when they began to detach from the dentin surface
• in incisors of 2 day old mice, ameloblasts detach from the labial dentin surface of the teeth, secrete bubble-like masses, and form cysts without the formation of a Tomes' process
• ameoblasts adjacent these cysts fail to properly mature
• ameoblasts also detach from the dentin of the first and second molars starting at postnatal day 7
• dentin is disorganized and fractured around the root of incisors in 30 day old mice
• dentin is also abnormally mineralized
• odontoblasts are sometimes trapped in the dentin resulting in an osteodentin phenotype
• the very thin enamel of young mice is quickly lost through attrition or fracturing
• most mice initially have very thin enamel on their teeth before losing it
• the enamel of incisors from 7 day old mice is aprismatic and amorphous
• the enamel of molars has a pitted appearance
• enamel lacks the rod-like that help characterize the enamel-dentin junction