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Allele Symbol Allele Name Allele ID |
Bsndtm1Tjj targeted mutation 1, Thomas J Jentsch MGI:3826849 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice fail to survive until adulthood
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• mice are moderately dehydrated
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit abnormal gain and phase of angular vestibulo ocular reflexes (VOR) in the dark compared to wild-type mice
• however, VORs in the light are normal
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• after 3 weeks, outer hair cells in the basal turn begin to degenerate
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• as the stria vascularis degenerates it loses the normal interdigitation of marginal and intermediate cells
• however, all cell types are retained
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• at 2 weeks, the width of the stria vascularis is reduced by 30% to 50% compared to in wild-type mice
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• between P20 and P30
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• at 3 weeks, mice exhibit hearing loss of about 60 dB as measured by auditory brainstem response that is less severe than in Slc12a2tm2Bhk homozygotes
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• at 3 to 4 weeks
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• mice exhibit abnormal gain and phase of angular vestibulo ocular reflexes (VOR) in the dark compared to wild-type mice
• however, VORs in the light are normal
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• after 3 weeks, outer hair cells in the basal turn begin to degenerate
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Bartter disease type 4a | DOID:0110145 |
OMIM:602522 |
J:143314 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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