About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Arg1tm1Pmu
targeted mutation 1, Peter J Murray
MGI:3826847
Summary 2 genotypes


Genotype
MGI:3826860
cn1
Allelic
Composition
Arg1tm1Pmu/Arg1tm1Pmu
Lyz2tm1(cre)Ifo/?
Genetic
Background
B6.Cg-Arg1tm1Pmu Lyz2tm1(cre)Ifo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arg1tm1Pmu mutation (2 available); any Arg1 mutation (6 available)
Lyz2tm1(cre)Ifo mutation (10 available); any Lyz2 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice are resistant to the wasting disease caused by systemic infection with T. gondii
• control mice lose 20% of their body weight by 40 days after T. gondii infection while infected mutant mice have no loss of body weight




Genotype
MGI:3826863
cn2
Allelic
Composition
Arg1tm1Pmu/Arg1tm1Pmu
Tg(Tek-cre)1Ywa/?
Genetic
Background
B6.Cg-Tg(Tek-cre)1Ywa Arg1tm1Pmu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arg1tm1Pmu mutation (2 available); any Arg1 mutation (6 available)
Tg(Tek-cre)1Ywa mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• very little urea is produced by peritoneal macrophages in response to IL-4 and IL-10 incubation due to a lack of arginase activity
• macrophages produce more nitrous oxide in response to LPS stimulation or Mycobacterium bovis infection
• mice infected with M. tuberculosis have lower bacterial counts than wild-type littermates in the lungs after the initial bacterial growth period
• there is also lower bacterial load in the spleens of the mice 70 days after infection with M. tuberculosis
• lung granulomas in these infected mice occupy a smaller fraction of the total lung area and have a more pronounced lymphocytic infiltrate

homeostasis/metabolism
• there is more NO activity in liver granulomas of mice infected with M. tuberculosis
• macrophages produce more nitrous oxide in response to LPS stimulation or Mycobacterium bovis infection

hematopoietic system
• very little urea is produced by peritoneal macrophages in response to IL-4 and IL-10 incubation due to a lack of arginase activity
• macrophages produce more nitrous oxide in response to LPS stimulation or Mycobacterium bovis infection





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/04/2020
MGI 6.15
The Jackson Laboratory