Analysis Tools
homeostasis/metabolism
|
• early (0 to 60 minutes) concentrations of a drug mixture, which contains midazolam, phenacetin, metaprodol, chlorzoxazone and tolbutamide, administered intravenously are higher than in wild-type mice
• at 2 hours, concentrations of the drug mixture administered intravenously was lower than in wild-type mice
• mice exhibit faster drug clearance and AUC (except in the case of midazolam) compared to wild-type mice
• the half-lives of phenacetin, tolbutamide, chlorzozane and midazolam are longer than in wild-type mice
• metabolite production following administration of drugs intravenously is shifted to the right compared to in wild-type mice
• when the drug mixture is given orally, AUC, Cmax are higher and clearance is slower than in wild-type mice for midazolam, phenacetin and metoprolol
• AUC and Cmax for tolbutamide given orally are lower than in wild-type mice
• when tolbutamide is administered orally or intravenously on its own, AUC and Cmax are increased and clearance is decreased compared to in wild-type mice
• mice exhibit a 4-fold increase in bioavailability of orally administered midazolam compared to in wild-type mice
• mice exhibit a 50% decrease in bioavailability of tolbutamide when delivered in a mixture and a 100% increase in bioavailability when administered on its own compared to in wild-type mice
|
liver/biliary system
| N |
• liver morphology is normal
|
