Phenotypes associated with this allele

• Allele Symbol: Tspan33^tm1Stsa
• Allele Name: targeted mutation 1, Schickwann Tsai
• Allele ID: MGI:3826388
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tspan33^tm1Stsa/Tspan33^tm1Stsa	involves: 129S1/Sv * 129X1/SvJ	MGI:3826392

Genotype
MGI:3826392

hm1

• Allelic Composition: Tspan33^tm1Stsa/Tspan33^tm1Stsa
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

extramedullary hematopoiesis ( J:143158 )

anemia ( J:143158 )

abnormal erythrocyte morphology ( J:143158 )

• about 30% of young mice contain red blood cells that are basophilic, larger in size, and have a "target cell" like appearance reflecting a decrease in the cytoplasm to cell surface ratio; referred to as basophilic macrocytes

• the percentage of basophilic macrocytes increases with age

• in severe cases up to 60% of red blood cells are basophilic macrocytes

decreased erythrocyte cell number ( J:143158 )

• in mice at about 1 year of age but not at 3 months of age

• red blood cell numbers are lower in mice with basophilic macrocytes compared to wild type mice and homozygous mutants without basophilic macrocytes

decreased hematocrit ( J:143158 )

• in mice at about 1 year of age but not at 3 months of age

• hematocrit is lower in mice with basophilic macrocytes compared to wild type mice and homozygous mutants without basophilic macrocytes

leptocytosis ( J:143158 )

• about 30% of young mice contain red blood cells that have a "target cell" like appearance reflecting a decrease in the cytoplasm to cell surface ratio

macrocytosis ( J:143158 )

• about 30% of young mice contain erythocytes that are larger than normal

thrombocytopenia ( J:143158 )

• most mice with severe anemia also have mild to moderate thrombocytopenia

increased monocyte cell number ( J:143158 )

• most mice with severe anemia also have mild to moderate monocytosis

reticulocytosis ( J:143158 )

• reticulocyte counts in anemic mice range between 5% and 60%

abnormal spleen morphology ( J:143158 )

• some spleens show signs of infarctions

enlarged spleen ( J:143158 )

• seen in mice with high percentages of basophilic macrocytes and anemia

• in some cases the spleen weighs more than 5 g

abnormal splenic cell ratio ( J:143158 )

• in spleens of anemic mice T and B lymphocytes are replaced with intensely basophilic and sometimes dysplastic erythroblasts and proerythroblasts

neoplasm

increased liver tumor incidence ( J:143158 )

• in 2 mice with extramedullary hematopoiesis in the liver, pedunculated liver tumors were seen

immune system

increased monocyte cell number ( J:143158 )

• most mice with severe anemia also have mild to moderate monocytosis

abnormal spleen morphology ( J:143158 )

• some spleens show signs of infarctions

enlarged spleen ( J:143158 )

• seen in mice with high percentages of basophilic macrocytes and anemia

• in some cases the spleen weighs more than 5 g

abnormal splenic cell ratio ( J:143158 )

• in spleens of anemic mice T and B lymphocytes are replaced with intensely basophilic and sometimes dysplastic erythroblasts and proerythroblasts

growth/size/body

enlarged spleen ( J:143158 )

• seen in mice with high percentages of basophilic macrocytes and anemia

• in some cases the spleen weighs more than 5 g

liver/biliary system

increased liver tumor incidence ( J:143158 )

• in 2 mice with extramedullary hematopoiesis in the liver, pedunculated liver tumors were seen