Mouse Genome Informatics
hm1
    Cftrtm1.1Cwr/Cftrtm1.1Cwr
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• only 32% of mice survive to day 40

digestive/alimentary system
• mice exhibit numerous intestinal blockages unlike in wild-type mice
• mice exhibit goblet hyperplasia in the intestine and increased luminal mucus accumulation compared to in wild-type mice

cellular
• following treatment with forskolin, nasal epithelium potential difference is not as great as in similarly treated wild-type mice
• intestinal epithelium fails to exhibit an increase in short-circuit current after stimulation with forskolin and IBMX unlike wild-type cells

growth/size/body
• growth is reduced 17% to 39% compared to in wild-type mice