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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cftrtm1.1Cwr
targeted mutation 1.1, Case Western Reserve University
MGI:3822761
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cftrtm1.1Cwr/Cftrtm1.1Cwr involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 MGI:3822763


Genotype
MGI:3822763
hm1
Allelic
Composition
Cftrtm1.1Cwr/Cftrtm1.1Cwr
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cftrtm1.1Cwr mutation (0 available); any Cftr mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• death occured from birth, with many dying at weaning age (20-30 days) due to intestinal obstruction
• only 32% of mice survive to day 40

respiratory system
• following treatment with a chloride-free solution containing forskolin, nasal epithelium potential difference is not changed as in similarly treated wild-type mice

digestive/alimentary system
• mice exhibit goblet hyperplasia in the intestine and increased luminal mucus accumulation compared to in wild-type mice
• mice exhibit numerous intestinal blockages unlike in wild-type mice
• intestinal epithelium fails to exhibit an increase in short-circuit current after stimulation with forskolin and IBMX unlike wild-type cells

growth/size/body
• growth is reduced 17% to 39% compared to in wild-type mice





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory