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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm1(Hesx1)Jpmb
targeted mutation 1, Juan Pedro Martinez Barbera
MGI:3822482
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm1(Hesx1)Jpmb/Gt(ROSA)26Sor+
Tmem163Tg(ACTB-cre)2Mrt/0 		involves: 129S/SvEv * C57BL/6 * SJL MGI:3822767
cn2
 		Gt(ROSA)26Sortm1(Hesx1)Jpmb/Gt(ROSA)26Sortm1(Hesx1)Jpmb
Tmem163Tg(ACTB-cre)2Mrt/0 		involves: 129S/SvEv * C57BL/6 * SJL MGI:3822768
cn3
 		Gt(ROSA)26Sortm1(Hesx1)Jpmb/Gt(ROSA)26Sor+
Hesx1tm1(cre)Jpmb/Hesx1tm1(cre)Jpmb 		involves: 129S/SvEv * C57BL/6 * SJL MGI:3822769
cn4
 		Gt(ROSA)26Sortm1(Hesx1)Jpmb/Gt(ROSA)26Sortm1(Hesx1)Jpmb
Hesx1tm1(cre)Jpmb/Hesx1tm1(cre)Jpmb 		involves: 129S/SvEv * C57BL/6 * SJL MGI:3822770


Genotype
MGI:3822767
cn1
Allelic
Composition		 Gt(ROSA)26Sortm1(Hesx1)Jpmb/Gt(ROSA)26Sor+
Tmem163Tg(ACTB-cre)2Mrt/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Hesx1)Jpmb mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Tmem163Tg(ACTB-cre)2Mrt mutation (3 available); any Tmem163 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
exencephaly ( J:135132 )
• 10% of embryos exhibit exencephaly
• Background Sensitivity: phenotype is background-dependent, as mutants on C57BL/6J;CD-1 background do not display exencephaly




Genotype
MGI:3822768
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1(Hesx1)Jpmb/Gt(ROSA)26Sortm1(Hesx1)Jpmb
Tmem163Tg(ACTB-cre)2Mrt/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Hesx1)Jpmb mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Tmem163Tg(ACTB-cre)2Mrt mutation (3 available); any Tmem163 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
exencephaly ( J:135132 )
• 80% of embryos exhibit exencephaly
• Background Sensitivity: phenotype is background-dependent, as mutants on C57BL/6J;CD-1 background do not display exencephaly




Genotype
MGI:3822769
cn3
Allelic
Composition		 Gt(ROSA)26Sortm1(Hesx1)Jpmb/Gt(ROSA)26Sor+
Hesx1tm1(cre)Jpmb/Hesx1tm1(cre)Jpmb
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Hesx1)Jpmb mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Hesx1tm1(cre)Jpmb mutation (0 available); any Hesx1 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:135132 )
• mice surviving to weaning age are reduced in number when compared to expected numbers

vision/eye
abnormal eye morphology ( J:135132 )
• all mutants surviving to weaninig age display eye defects




Genotype
MGI:3822770
cn4
Allelic
Composition		 Gt(ROSA)26Sortm1(Hesx1)Jpmb/Gt(ROSA)26Sortm1(Hesx1)Jpmb
Hesx1tm1(cre)Jpmb/Hesx1tm1(cre)Jpmb
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Hesx1)Jpmb mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Hesx1tm1(cre)Jpmb mutation (0 available); any Hesx1 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:135132 )
N
• number of mice identified at weaning is similar to the expected numbers

vision/eye
abnormal eye morphology ( J:135132 )
• all mutants surviving to weaninig age display eye defects
microphthalmia ( J:135132 )
• bilateral microphthalmia was seen in some embryos
anophthalmia ( J:135132 )
• some embryos show bilateral anophthalmia, whereas others have unilateral anophthalmia




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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory