About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(CAG-cat,-Ptpn11*Q97R)1Rbns
transgene insertion 1, Jeffrey Robbins
MGI:3822129
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Mapk1tm1Melo/Mapk1+
Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0
Tg(Tek-cre)12Flv/0
involves: 129S2/SvPas * C3H * C57BL/6 * FVB/N MGI:3822161
cn2
Mapk3tm1Gpg/Mapk3tm1Gpg
Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0
Tg(Tek-cre)12Flv/0
involves: 129/Sv * C3H * C57BL/6 * FVB/N MGI:3822162
cn3
Mapk3tm1Gpg/Mapk3+
Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0
Tg(Tek-cre)12Flv/0
involves: 129/Sv * C3H * C57BL/6 * FVB/N MGI:3822163
cn4
Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0
Tg(Tek-cre)12Flv/0
involves: C3H * C57BL/6 * FVB/N MGI:3822157
cn5
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0
involves: C57BL/6J * CBA/J * FVB/N MGI:4361520


Genotype
MGI:3822161
cn1
Allelic
Composition
Mapk1tm1Melo/Mapk1+
Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0
Tg(Tek-cre)12Flv/0
Genetic
Background
involves: 129S2/SvPas * C3H * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk1tm1Melo mutation (0 available); any Mapk1 mutation (40 available)
Tg(CAG-cat,-Ptpn11*Q97R)1Rbns mutation (0 available)
Tg(Tek-cre)12Flv mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
• the frequency of double outlet right ventricles is greater than in Tg(CAG-cat,-Ptpn11*Q97R)1Rbns Tg(Tek-cre)12Flv mice
• the frequency of ventricular septal defects is greater than in Tg(CAG-cat,-Ptpn11*Q97R)1Rbns Tg(Tek-cre)12Flv mice
• proliferation of endothelial, mesenchymal, and cardiomyocyte cells is increased while apoptosis rates are decreased compared to in wild-type

liver/biliary system

homeostasis/metabolism
• mice exhibit nuchal edema

integument
• mice exhibit nuchal edema

growth/size/body
• mice exhibit nuchal edema

cellular




Genotype
MGI:3822162
cn2
Allelic
Composition
Mapk3tm1Gpg/Mapk3tm1Gpg
Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0
Tg(Tek-cre)12Flv/0
Genetic
Background
involves: 129/Sv * C3H * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk3tm1Gpg mutation (1 available); any Mapk3 mutation (26 available)
Tg(CAG-cat,-Ptpn11*Q97R)1Rbns mutation (0 available)
Tg(Tek-cre)12Flv mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• all mice died by E14.5
• however, Mendelian ratios of embryos are present at E13.5

cardiovascular system
N
• mice exhibit normal endocardial cushion size and rates of proliferation and apoptosis of endothelial and mesenchymal cushion cells

liver/biliary system

homeostasis/metabolism
• mice exhibit nuchal edema

integument
• mice exhibit nuchal edema

growth/size/body
• mice exhibit nuchal edema

cellular




Genotype
MGI:3822163
cn3
Allelic
Composition
Mapk3tm1Gpg/Mapk3+
Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0
Tg(Tek-cre)12Flv/0
Genetic
Background
involves: 129/Sv * C3H * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk3tm1Gpg mutation (1 available); any Mapk3 mutation (26 available)
Tg(CAG-cat,-Ptpn11*Q97R)1Rbns mutation (0 available)
Tg(Tek-cre)12Flv mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
• endocardial cushion volume is increased compared to in wild-type mice but not as severely as in Tg(CAG-cat,-Ptpn11*Q97R)1Rbns Tg(Tek-cre)12Flv mice

liver/biliary system

homeostasis/metabolism
• mice exhibit nuchal edema

integument
• mice exhibit nuchal edema

growth/size/body
• mice exhibit nuchal edema

cellular




Genotype
MGI:3822157
cn4
Allelic
Composition
Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0
Tg(Tek-cre)12Flv/0
Genetic
Background
involves: C3H * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-cat,-Ptpn11*Q97R)1Rbns mutation (0 available)
Tg(Tek-cre)12Flv mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer than expected mice are present at E13.5 and no mice are present after birth

cardiovascular system
• outflow tract cushion volume is only increased by 39% compared to in wild-type mice
• at E13.5, valve primordial has not yet undergone differentiation and extracellular remodeling as in wild-type mice
• cushion volume is increased up to 85% compared to in wild-type mice
• in some mice
• proliferation of endothelial, mesenchymal, and cardiomyocyte cells is increased compared to in wild-type
• proliferation of cells in the atrioventricular canal cushion endothelial and mesenchymal cell proliferation is increased while apoptosis is decreased compared to in wild-type mice
• however, proliferation of cardiomyocytes in the atrioventricular canal cushion is normal
• at E13.5
• some mice exhibit ventricular noncompaction

embryo

growth/size/body
• at E13.5

homeostasis/metabolism
• at E13.5, mice exhibit nuchal and back edema
• at E13.5

liver/biliary system
• at E13.5

muscle
• some mice exhibit ventricular noncompaction

integument
• at E13.5

cellular

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Noonan syndrome 1 DOID:0060578 OMIM:163950
J:142212




Genotype
MGI:4361520
cn5
Allelic
Composition
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0
Genetic
Background
involves: C57BL/6J * CBA/J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Tg(CAG-cat,-Ptpn11*Q97R)1Rbns mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice that exhibit a cleft palate die within 5 days of birth

craniofacial
• mice exhibit craniofacial defects that become more pronounced with age
• however, treatment with U0126 restores skull size, length, mandibular bone length, inner canthal distance, and frontal bone height
• at E17.5 and P2, mice exhibit abnormal skull morphology
• however, treatment with U0126 restores skull size, length, mandibular bone length, inner canthal distance, and frontal bone height
• mice exhibit a reduced skull length compared to in wild-type mice
• however, treatment with U0126 restores frontal bone morphology
• mice exhibit larger than normal anterior fontanelle
• however, treatment with U0126 restores normal anterior fontanelle morphology
• mice exhibit taller frontal bone heights compared with wild-type mice
• however, treatment with U0126 restores frontal bone morphology
• proportional to the small skull length
• however, treatment with U0126 restores mandible length
• dome-shaped head
• in 21% of mice
• in 21% of mice
• nasal cartilage and bones do not fuse along the midline unlike in wild-type mice
• nasal cartilage and bones do not fuse along the midline unlike in wild-type mice
• mice have a broad nose

skeleton
• at E17.5 and P2, mice exhibit abnormal skull morphology
• however, treatment with U0126 restores skull size, length, mandibular bone length, inner canthal distance, and frontal bone height
• mice exhibit a reduced skull length compared to in wild-type mice
• however, treatment with U0126 restores frontal bone morphology
• mice exhibit larger than normal anterior fontanelle
• however, treatment with U0126 restores normal anterior fontanelle morphology
• mice exhibit taller frontal bone heights compared with wild-type mice
• however, treatment with U0126 restores frontal bone morphology
• proportional to the small skull length
• however, treatment with U0126 restores mandible length
• dome-shaped head
• nasal cartilage and bones do not fuse along the midline unlike in wild-type mice

growth/size/body
• in 21% of mice
• in 21% of mice
• nasal cartilage and bones do not fuse along the midline unlike in wild-type mice
• nasal cartilage and bones do not fuse along the midline unlike in wild-type mice
• mice have a broad nose
• mice exhibit a reduced body weight that is partially restored by treatment with U0126
• webbed neck
• mice exhibit a short stature that is partially restored by treatment with U0126
• pronounced at P2
• slightly at E17.5

embryo
• neural crest cells fail to contribute to the parietal bone unlike in wild-type mice

hearing/vestibular/ear

vision/eye
• mice exhibit hypetelorism compared with wild-type mice
• mice exhibit a greater inner canthal distance compared with wild-type mice
• however, treatment with U0126 restores inner canthal distance

digestive/alimentary system
• in 21% of mice

respiratory system
• nasal cartilage and bones do not fuse along the midline unlike in wild-type mice
• nasal cartilage and bones do not fuse along the midline unlike in wild-type mice

integument
• webbed neck

cellular
• neural crest cells fail to contribute to the parietal bone unlike in wild-type mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Noonan syndrome 1 DOID:0060578 OMIM:163950
J:153094





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory