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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(CAG-cat,-Ptpn11*Q97R)1Rbns
transgene insertion 1, Jeffrey Robbins
MGI:3822129
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Mapk3tm1Gpg/Mapk3tm1Gpg
Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0
Tg(Tek-cre)12Flv/0
involves: 129/Sv * C3H * C57BL/6 * FVB/N MGI:3822162
cn2
Mapk3tm1Gpg/Mapk3+
Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0
Tg(Tek-cre)12Flv/0
involves: 129/Sv * C3H * C57BL/6 * FVB/N MGI:3822163
cn3
Mapk1tm1Melo/Mapk1+
Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0
Tg(Tek-cre)12Flv/0
involves: 129S2/SvPas * C3H * C57BL/6 * FVB/N MGI:3822161
cn4
Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0
Tg(Tek-cre)12Flv/0
involves: C3H * C57BL/6 * FVB/N MGI:3822157
cn5
Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0
Tg(Wnt1-cre)11Rth/0
involves: C57BL/6J * CBA/J * FVB/N MGI:4361520


Genotype
MGI:3822162
cn1
Allelic
Composition
Mapk3tm1Gpg/Mapk3tm1Gpg
Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0
Tg(Tek-cre)12Flv/0
Genetic
Background
involves: 129/Sv * C3H * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk3tm1Gpg mutation (1 available); any Mapk3 mutation (8 available)
Tg(CAG-cat,-Ptpn11*Q97R)1Rbns mutation (0 available)
Tg(Tek-cre)12Flv mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• all mice died by E14.5 (J:142212)
• however, Mendelian ratios of embryos are present at E13.5 (J:142212)
• all mice died by E14.5 (J:142212)
• however, Mendelian ratios of embryos are present at E13.5 (J:142212)

cardiovascular system
N
• mice exhibit normal endocardial cushion size and rates of proliferation and apoptosis of endothelial and mesenchymal cushion cells (J:142212)
• mice exhibit normal endocardial cushion size and rates of proliferation and apoptosis of endothelial and mesenchymal cushion cells (J:142212)

liver/biliary system

homeostasis/metabolism
• mice exhibit nuchal edema (J:142212)
• mice exhibit nuchal edema (J:142212)

integument
• mice exhibit nuchal edema (J:142212)
• mice exhibit nuchal edema (J:142212)

growth/size/body
• mice exhibit nuchal edema (J:142212)
• mice exhibit nuchal edema (J:142212)




Genotype
MGI:3822163
cn2
Allelic
Composition
Mapk3tm1Gpg/Mapk3+
Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0
Tg(Tek-cre)12Flv/0
Genetic
Background
involves: 129/Sv * C3H * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk3tm1Gpg mutation (1 available); any Mapk3 mutation (8 available)
Tg(CAG-cat,-Ptpn11*Q97R)1Rbns mutation (0 available)
Tg(Tek-cre)12Flv mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• all mice died by E14.5 (J:142212)
• all mice died by E14.5 (J:142212)

cardiovascular system
• endocardial cushion volume is increased compared to in wild-type mice but not as severely as in Tg(CAG-cat,-Ptpn11*Q97R)1Rbns Tg(Tek-cre)12Flv mice (J:142212)
• endocardial cushion volume is increased compared to in wild-type mice but not as severely as in Tg(CAG-cat,-Ptpn11*Q97R)1Rbns Tg(Tek-cre)12Flv mice (J:142212)

liver/biliary system

homeostasis/metabolism
• mice exhibit nuchal edema (J:142212)
• mice exhibit nuchal edema (J:142212)

integument
• mice exhibit nuchal edema (J:142212)
• mice exhibit nuchal edema (J:142212)

growth/size/body
• mice exhibit nuchal edema (J:142212)
• mice exhibit nuchal edema (J:142212)




Genotype
MGI:3822161
cn3
Allelic
Composition
Mapk1tm1Melo/Mapk1+
Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0
Tg(Tek-cre)12Flv/0
Genetic
Background
involves: 129S2/SvPas * C3H * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk1tm1Melo mutation (0 available); any Mapk1 mutation (19 available)
Tg(CAG-cat,-Ptpn11*Q97R)1Rbns mutation (0 available)
Tg(Tek-cre)12Flv mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• all mice died by E14.5 (J:142212)
• all mice died by E14.5 (J:142212)

cardiovascular system
• the frequency of double outlet right ventricles is greater than in Tg(CAG-cat,-Ptpn11*Q97R)1Rbns Tg(Tek-cre)12Flv mice (J:142212)
• the frequency of double outlet right ventricles is greater than in Tg(CAG-cat,-Ptpn11*Q97R)1Rbns Tg(Tek-cre)12Flv mice (J:142212)
• the frequency of ventricular septal defects is greater than in Tg(CAG-cat,-Ptpn11*Q97R)1Rbns Tg(Tek-cre)12Flv mice (J:142212)
• the frequency of ventricular septal defects is greater than in Tg(CAG-cat,-Ptpn11*Q97R)1Rbns Tg(Tek-cre)12Flv mice (J:142212)
• proliferation of endothelial, mesenchymal, and cardiomyocyte cells is increased while apoptosis rates are decreased compared to in wild-type (J:142212)
• proliferation of endothelial, mesenchymal, and cardiomyocyte cells is increased while apoptosis rates are decreased compared to in wild-type (J:142212)

liver/biliary system

homeostasis/metabolism
• mice exhibit nuchal edema (J:142212)
• mice exhibit nuchal edema (J:142212)

integument
• mice exhibit nuchal edema (J:142212)
• mice exhibit nuchal edema (J:142212)

growth/size/body
• mice exhibit nuchal edema (J:142212)
• mice exhibit nuchal edema (J:142212)




Genotype
MGI:3822157
cn4
Allelic
Composition
Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0
Tg(Tek-cre)12Flv/0
Genetic
Background
involves: C3H * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-cat,-Ptpn11*Q97R)1Rbns mutation (0 available)
Tg(Tek-cre)12Flv mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer than expected mice are present at E13.5 and no mice are present after birth (J:142212)
• fewer than expected mice are present at E13.5 and no mice are present after birth (J:142212)
• all mice died by E14.5 (J:142212)
• all mice died by E14.5 (J:142212)

cardiovascular system
• at E13.5, valve primordial has not yet undergone differentiation and extracellular remodeling as in wild-type mice (J:142212)
• at E13.5, valve primordial has not yet undergone differentiation and extracellular remodeling as in wild-type mice (J:142212)
• cushion volume is increased up to 85% compared to in wild-type mice (J:142212)
• cushion volume is increased up to 85% compared to in wild-type mice (J:142212)
• outflow tract cushion volume is only increased by 39% compared to in wild-type mice (J:142212)
• outflow tract cushion volume is only increased by 39% compared to in wild-type mice (J:142212)
• in some mice (J:142212)
• in some mice (J:142212)
• in some mice (J:142212)
• in some mice (J:142212)
• proliferation of endothelial, mesenchymal, and cardiomyocyte cells is increased compared to in wild-type (J:142212)
• proliferation of cells in the atrioventricular canal cushion endothelial and mesenchymal cell proliferation is increased while apoptosis is decreased compared to in wild-type mice (J:142212)
• however, proliferation of cardiomyocytes in the atrioventricular canal cushion is normal (J:142212)
• proliferation of endothelial, mesenchymal, and cardiomyocyte cells is increased compared to in wild-type (J:142212)
• proliferation of cells in the atrioventricular canal cushion endothelial and mesenchymal cell proliferation is increased while apoptosis is decreased compared to in wild-type mice (J:142212)
• however, proliferation of cardiomyocytes in the atrioventricular canal cushion is normal (J:142212)
• at E13.5 (J:142212)
• at E13.5 (J:142212)
• some mice exhibit ventricular noncompaction (J:142212)
• some mice exhibit ventricular noncompaction (J:142212)

embryogenesis
• at E13.5 (J:142212)
• at E13.5 (J:142212)

growth/size/body
• at E13.5 (J:142212)
• at E13.5 (J:142212)
• at E13.5 (J:142212)
• at E13.5 (J:142212)

homeostasis/metabolism
• at E13.5, mice exhibit nuchal and back edema (J:142212)
• at E13.5, mice exhibit nuchal and back edema (J:142212)
• at E13.5 (J:142212)
• at E13.5 (J:142212)

liver/biliary system
• at E13.5 (J:142212)
• at E13.5 (J:142212)

muscle
• some mice exhibit ventricular noncompaction (J:142212)
• some mice exhibit ventricular noncompaction (J:142212)

integument
• at E13.5 (J:142212)
• at E13.5 (J:142212)

Mouse Models of Human Disease
OMIM ID Ref(s)
Noonan Syndrome 1; NS1 163950 J:142212




Genotype
MGI:4361520
cn5
Allelic
Composition
Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0
Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: C57BL/6J * CBA/J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-cat,-Ptpn11*Q97R)1Rbns mutation (0 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice that exhibit a cleft palate die within 5 days of birth (J:153094)
• mice that exhibit a cleft palate die within 5 days of birth (J:153094)

craniofacial
• mice exhibit craniofacial defects that become more pronounced with age (J:153094)
• however, treatment with U0126 restores skull size, length, mandibular bone length, inner canthal distance, and frontal bone height (J:153094)
• mice exhibit craniofacial defects that become more pronounced with age (J:153094)
• however, treatment with U0126 restores skull size, length, mandibular bone length, inner canthal distance, and frontal bone height (J:153094)
• at E17.5 and P2, mice exhibit abnormal skull morphology (J:153094)
• however, treatment with U0126 restores skull size, length, mandibular bone length, inner canthal distance, and frontal bone height (J:153094)
• at E17.5 and P2, mice exhibit abnormal skull morphology (J:153094)
• however, treatment with U0126 restores skull size, length, mandibular bone length, inner canthal distance, and frontal bone height (J:153094)
• mice exhibit a reduced skull length compared to in wild-type mice (J:153094)
• however, treatment with U0126 restores frontal bone morphology (J:153094)
• mice exhibit a reduced skull length compared to in wild-type mice (J:153094)
• however, treatment with U0126 restores frontal bone morphology (J:153094)
• mice exhibit larger than normal anterior fontanelle (J:153094)
• however, treatment with U0126 restores normal anterior fontanelle morphology (J:153094)
• mice exhibit larger than normal anterior fontanelle (J:153094)
• however, treatment with U0126 restores normal anterior fontanelle morphology (J:153094)
• mice exhibit taller frontal bone heights compared with wild-type mice (J:153094)
• however, treatment with U0126 restores frontal bone morphology (J:153094)
• mice exhibit taller frontal bone heights compared with wild-type mice (J:153094)
• however, treatment with U0126 restores frontal bone morphology (J:153094)
• proportional to the small skull length (J:153094)
• however, treatment with U0126 restores mandible length (J:153094)
• proportional to the small skull length (J:153094)
• however, treatment with U0126 restores mandible length (J:153094)
• dome-shaped head (J:153094)
• dome-shaped head (J:153094)
• in 21% of mice (J:153094)
• in 21% of mice (J:153094)
• in 21% of mice (J:153094)
• in 21% of mice (J:153094)
• nasal bones fails to fuse along the midline unlike in wild-type mice (J:153094)
• mice have a broad nose (J:153094)
• nasal bones fails to fuse along the midline unlike in wild-type mice (J:153094)
• mice have a broad nose (J:153094)
• nasal cartilage fails to fuse along the midline unlike in wild-type mice (J:153094)
• nasal cartilage fails to fuse along the midline unlike in wild-type mice (J:153094)

skeleton
• at E17.5 and P2, mice exhibit abnormal skull morphology (J:153094)
• however, treatment with U0126 restores skull size, length, mandibular bone length, inner canthal distance, and frontal bone height (J:153094)
• at E17.5 and P2, mice exhibit abnormal skull morphology (J:153094)
• however, treatment with U0126 restores skull size, length, mandibular bone length, inner canthal distance, and frontal bone height (J:153094)
• mice exhibit a reduced skull length compared to in wild-type mice (J:153094)
• however, treatment with U0126 restores frontal bone morphology (J:153094)
• mice exhibit a reduced skull length compared to in wild-type mice (J:153094)
• however, treatment with U0126 restores frontal bone morphology (J:153094)
• mice exhibit larger than normal anterior fontanelle (J:153094)
• however, treatment with U0126 restores normal anterior fontanelle morphology (J:153094)
• mice exhibit larger than normal anterior fontanelle (J:153094)
• however, treatment with U0126 restores normal anterior fontanelle morphology (J:153094)
• mice exhibit taller frontal bone heights compared with wild-type mice (J:153094)
• however, treatment with U0126 restores frontal bone morphology (J:153094)
• mice exhibit taller frontal bone heights compared with wild-type mice (J:153094)
• however, treatment with U0126 restores frontal bone morphology (J:153094)
• however, treatment with U0126 restores mandible length (J:153094)
• proportional to the small skull length (J:153094)
• proportional to the small skull length (J:153094)
• however, treatment with U0126 restores mandible length (J:153094)
• dome-shaped head (J:153094)
• dome-shaped head (J:153094)
• nasal cartilage fails to fuse along the midline unlike in wild-type mice (J:153094)
• nasal cartilage fails to fuse along the midline unlike in wild-type mice (J:153094)

growth/size/body
• in 21% of mice (J:153094)
• in 21% of mice (J:153094)
• in 21% of mice (J:153094)
• in 21% of mice (J:153094)
• nasal bones fails to fuse along the midline unlike in wild-type mice (J:153094)
• mice have a broad nose (J:153094)
• nasal bones fails to fuse along the midline unlike in wild-type mice (J:153094)
• mice have a broad nose (J:153094)
• nasal cartilage fails to fuse along the midline unlike in wild-type mice (J:153094)
• nasal cartilage fails to fuse along the midline unlike in wild-type mice (J:153094)
• mice exhibit a reduced body weight that is partially restored by treatment with U0126 (J:153094)
• mice exhibit a reduced body weight that is partially restored by treatment with U0126 (J:153094)
• webbed neck (J:153094)
• webbed neck (J:153094)
• mice exhibit a short stature that is partially restored by treatment with U0126 (J:153094)
• mice exhibit a short stature that is partially restored by treatment with U0126 (J:153094)
• pronounced at P2 (J:153094)
• pronounced at P2 (J:153094)
• slightly at E17.5 (J:153094)
• slightly at E17.5 (J:153094)

embryogenesis
• neural crest cells fail to contribute to the parietal bone unlike in wild-type mice (J:153094)
• neural crest cells fail to contribute to the parietal bone unlike in wild-type mice (J:153094)

hearing/vestibular/ear

vision/eye
• mice exhibit hypetelorism and a greater inner canthal distance compared with wild-type mice (J:153094)
• however, treatment with U0126 restores inner canthal distance (J:153094)
• mice exhibit hypetelorism and a greater inner canthal distance compared with wild-type mice (J:153094)
• however, treatment with U0126 restores inner canthal distance (J:153094)

digestive/alimentary system
• in 21% of mice (J:153094)
• in 21% of mice (J:153094)

respiratory system
• nasal bones fails to fuse along the midline unlike in wild-type mice (J:153094)
• mice have a broad nose (J:153094)
• nasal bones fails to fuse along the midline unlike in wild-type mice (J:153094)
• mice have a broad nose (J:153094)
• nasal cartilage fails to fuse along the midline unlike in wild-type mice (J:153094)
• nasal cartilage fails to fuse along the midline unlike in wild-type mice (J:153094)

integument
• webbed neck (J:153094)
• webbed neck (J:153094)

cellular
• neural crest cells fail to contribute to the parietal bone unlike in wild-type mice (J:153094)
• neural crest cells fail to contribute to the parietal bone unlike in wild-type mice (J:153094)

Mouse Models of Human Disease
OMIM ID Ref(s)
Noonan Syndrome 1; NS1 163950 J:153094





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory