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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Snap25tm1.1Bark
targeted mutation 1.1, Christina Bark
MGI:3821974
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Snap25tm1.1Bark/Snap25tm1.1Bark B6.Cg-Snap25tm1.1Bark MGI:3821976
hm2
Snap25tm1.1Bark/Snap25tm1.1Bark Not Specified MGI:5766495


Genotype
MGI:3821976
hm1
Allelic
Composition
Snap25tm1.1Bark/Snap25tm1.1Bark
Genetic
Background
B6.Cg-Snap25tm1.1Bark
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snap25tm1.1Bark mutation (0 available); any Snap25 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• on days 2 and 4 of a Morris water maze test, mice exhibit a higher latency to navigate to the visible platform and longer swim distances compared to wild-type mice
• spatial learning deficits are more pronounced in female mice
• in an elevated plus maze, mice spend more time in closed arms than open arms compared to wild-type mice
• in a Morris water maze test
• mice exhibit reduced motility, locomotion and rearing compared to wild-type mice
• mice exhibit seizures but less frequently and at a later stage than those observed in Snap25tm1Bark homozygotes

nervous system
• mice exhibit seizures but less frequently and at a later stage than those observed in Snap25tm1Bark homozygotes
• in the stratum lucidum of CA3, 2 and 4 month old mice exhibit expanded mossy fibers that form large bundles and separate the synaptophysin+ nerve endings into island-like structures unlike in wild-type mice
• pathological changes are progressive with age
• at 0.2 Hz but not 0.5 Hz

growth/size/body
• female mice weigh slightly less than wild-type mice
• however, male weights are normal




Genotype
MGI:5766495
hm2
Allelic
Composition
Snap25tm1.1Bark/Snap25tm1.1Bark
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snap25tm1.1Bark mutation (0 available); any Snap25 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• increase in amounts of mesenteric adipose tissue, peri-gonadal adipose tissue, retroperitoneal adipose tissue, and subcutaneous adipose tissue in mice fed the standard diet with a further increase on the Western diet, indicating central/abdominal obesity
• mice on the standard diet exhibit enlarged adipose cell size in the subcutaneous and peri-gonadal adipose tissue
• a further increase in adipocyte cell size is seen on the Western diet

behavior/neurological
• average food and calorie intake of standard-diet fed males is lower than in wild-type mice
• average food and calorie intake of standard diet-fed females is increased compared to wild-type females
• average food and calorie intake of Western diet-fed males and females is increased compared to Western diet-fed wild-type mice

endocrine/exocrine glands
• increase in pancreas insulin content in mice on a standard diet

growth/size/body
• standard diet and Western diet-fed mice show increased body mass index
• standard diet-fed females show increased body weight around week 4 of the diet while males do at week 5 of the diet
• high-fat/high-sucrose (Western) diet-fed mice show a dramatic increase in body weight, with significant increases in females after only 1 week and in males after 3 weeks of the diet

homeostasis/metabolism
• increase in pancreas insulin content in mice on a standard diet
• high-fat/high-sucrose (Western) diet-fed mice show a dramatic increase in body weight, with significant increases in females after only 1 week and in males after 3 weeks of the diet
• females exhibit an increase in basal blood glucose levels
• both primary (genetic) and secondary (dietary) preprandial hyperglycemia becomes significant after 3 weeks of diet intervention in males and at 6 weeks in females
• standard diet-fed mice exhibit a decrease in basal serum ghrelin levels
• males on a Western diet show an increase in basal serum insulin levels
• female, but not male, standard diet-fed mice show increased leptin levels
• Western diet-fed males and females show an 8-fold increase in basal leptin levels
• males fed the standard diet for 7 weeks exhibit higher blood cholesterol levels in week 3 of the diet while females do at week 4
• mice fed the Western diet exhibit severe increases in blood cholesterol levels
• preprandial blood cholesterol levels are increased
• males fed the standard diet for 7 weeks exhibit hypertriglyceridemia in week 5 of the diet while females do at week 3
• mice fed the Western diet exhibit severe hypertriglyceridemia
• preprandial blood triglyceride levels are increased
• mice fed a standard diet show lower blood glucose levels 15 min after glucose challenge
• males on the Western diet exhibit a severe inability to maintain normal blood glucose levels despite a 16-fold increase in insulin secretion during glucose tolerance testing, indicating insulin resistance

liver/biliary system
• mice develop hepatic steatosis which progresses to severe fatty liver disease when mice are fed a Western diet





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last database update
11/10/2020
MGI 6.16
The Jackson Laboratory