Analysis Tools
homeostasis/metabolism
| N |
• no abnormal metabolic parameters
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Allele Symbol Allele Name Allele ID |
Ffar1tm1Dgen targeted mutation 1, Deltagen MGI:3821733 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• no abnormal metabolic parameters
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• attenuated amylin release when plasma free fatty acids become elevated
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| N |
• glucose tolerance is not improved over controls regardless of diet
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• attenuated amylin release when plasma free fatty acids become elevated
• reduced GLP-1 levels when plasma free fatty acids become elevated
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• when plasma free fatty acids become elevated
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• the increase in plasma insulin resulting from elevated plasma free fatty acids is only half the increase seen in controls
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• on a low fat diet
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• in the liver when on a low fat diet
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• higher food intake than controls on a low fat diet
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• in the liver when on a low fat diet
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• show a diminished preference for linoleic acid in a 2 bottle preference test
• glossopharyngeal nerve responses to oleic acid, linoleic acid, linolenic acid, or lauric acid are diminished compared to responses in control mice
• however, no differences are detected in the responses of the chorda tympani
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• indifferent to all concentrations of linoleic acid and oleic acid suggesting a profound defect in the ability to taste these fatty acids
• no differences are detected in taste sensitivity for bitter, sweet, sour, salty or umami
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• glossopharyngeal nerve responses to oleic acid, linoleic acid, linolenic acid, or lauric acid are diminished compared to responses in control mice
• however, no differences are detected in the responses of the chorda tympani
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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