Phenotypes associated with this allele

• Allele Symbol: Glrx^tm3Ysh
• Allele Name: targeted mutation 3, Ye-Shih Ho
• Allele ID: MGI:3820704
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Glrx^tm3Ysh/Glrx^tm3Ysh	involves: 129S1/Sv * 129X1/SvJ	MGI:3820709

Genotype
MGI:3820709

hm1

• Allelic Composition: Glrx^tm3Ysh/Glrx^tm3Ysh
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal lens epithelium morphology ( J:141903 )

• cells larger

• cells round rather than elongated

cellular

abnormal plasma membrane morphology ( J:141903 )

• reduced cell membrane integrity in lens epithelial cells in culture

abnormal cell physiology ( J:141903 )

• reduced viability of lens epithelial cells in culture

abnormal cell migration ( J:141903 )

• lens epithelial cells in culture show slower migration

decreased cell proliferation ( J:141903 )

• doubling time for lens epithelial cells in culture is 33 hours compared to 13 hours for controls