About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Plin2tm1Itl
targeted mutation 1, inGenious Targeting Laboratory
MGI:3820655
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Plin2tm1Itl/Plin2tm1Itl involves: 129S6/SvEvTac * BALB/c MGI:3820657
hm2
Plin2tm1Itl/Plin2tm1Itl involves: 129S6/SvEvTac * C57BL/6 MGI:3820658
cx3
Plin2tm1Itl/Plin2tm1Itl
Rpe65tm1Tmr/Rpe65tm1Tmr
Tyrc-2J/Tyrc-2J
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * BALB/c * C57BL/6 MGI:3820659


Genotype
MGI:3820657
hm1
Allelic
Composition
Plin2tm1Itl/Plin2tm1Itl
Genetic
Background
involves: 129S6/SvEvTac * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plin2tm1Itl mutation (0 available); any Plin2 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
N
• despite disruptions in eye physiology, eye morphology is normal
• at 1 year of age, mice exhibit attenuated electroretinogram responses compared to wild-type mice affecting both a- and b-waves under scotopic conditions and b-waves under photopic conditions
• Background Sensitivity: delayed dark adaptation is more prominent on a mixed BALB/c background then on a mixed C57BL/6 background

homeostasis/metabolism
• under dark-adapted conditions, mice exhibit a decrease in all-trans-retinal but slower clearance of all-trans retinal and all-trans retinol compared to in wild-type mice results in a 20% increase in all-trans-retinal levels immediately after light illumination and a 40% increase 15 minutes after illumination
• newly formed retinyl esters assemble into more aggregates than in wild-type mice and these aggregates are highly mobile unlike in wild-type cells
• however, accumulation of A2E and iso-A2E is normal




Genotype
MGI:3820658
hm2
Allelic
Composition
Plin2tm1Itl/Plin2tm1Itl
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plin2tm1Itl mutation (0 available); any Plin2 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• Background Sensitivity: delayed dark adaptation is less prominent on a mixed C57BL/6 background then on a mixed BALB/c background




Genotype
MGI:3820659
cx3
Allelic
Composition
Plin2tm1Itl/Plin2tm1Itl
Rpe65tm1Tmr/Rpe65tm1Tmr
Tyrc-2J/Tyrc-2J
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plin2tm1Itl mutation (0 available); any Plin2 mutation (13 available)
Rpe65tm1Tmr mutation (0 available); any Rpe65 mutation (15 available)
Tyrc-2J mutation (12 available); any Tyr mutation (366 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• at 3 to 4 months, retinyl ester accumulation is 70% of the accumulation observed in Rpe65tm1Tmr homozygotes





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/17/2016
MGI 6.03
The Jackson Laboratory