Phenotypes associated with this allele

• Allele Symbol: Cnn2^tm1.2Jin
• Allele Name: targeted mutation 1.2, Jian-Ping Jin
• Allele ID: MGI:3820423
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cnn2^tm1.2Jin/Cnn2^tm1.2Jin	B6.129X1-Cnn2^tm1.2Jin	MGI:3820513

Genotype
MGI:3820513

hm1

• Allelic Composition: Cnn2^tm1.2Jin/Cnn2^tm1.2Jin
• Genetic Background: B6.129X1-Cnn2^tm1.2Jin

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:141867 )

N • normal peripheral eosinophiles and basophiles

N • normal phagocytic function in granulocytes

abnormal macrophage physiology ( J:141867 )

• reduced spreading in macrophage culture

• increased phagocytosis activity

abnormal macrophage chemotaxis ( J:141867 )

• faster macrophage migration as indicated by more rapid closure of scratch wounds

abnormal immune system cell morphology ( J:141867 )

decreased granulocyte number ( J:141867 )

• peritoneal granulocytes are reduced starting 12 hour after thioglycolate stimulation and continuing through 72 hours

decreased neutrophil cell number ( J:141867 )

• reduced peripheral neutrophiles

increased macrophage cell number ( J:141867 )

• proportionately elevated paritoneal macrophage level 72 hours after thioglycolate simulation

decreased monocyte cell number ( J:141867 )

• reduced peripheral monocytes

hematopoietic system

increased bone marrow cell number ( J:141867 )

• more rapid bone marrow cell proliferation

decreased granulocyte number ( J:141867 )

• peritoneal granulocytes are reduced starting 12 hour after thioglycolate stimulation and continuing through 72 hours

decreased neutrophil cell number ( J:141867 )

• reduced peripheral neutrophiles

increased macrophage cell number ( J:141867 )

• proportionately elevated paritoneal macrophage level 72 hours after thioglycolate simulation

decreased monocyte cell number ( J:141867 )

• reduced peripheral monocytes

abnormal macrophage physiology ( J:141867 )

• reduced spreading in macrophage culture

• increased phagocytosis activity

abnormal macrophage chemotaxis ( J:141867 )

• faster macrophage migration as indicated by more rapid closure of scratch wounds

homeostasis/metabolism

enhanced wound healing ( J:141867 )

• quicker closure of scratch wounds

cellular

abnormal macrophage chemotaxis ( J:141867 )

• faster macrophage migration as indicated by more rapid closure of scratch wounds