Phenotypes associated with this allele

• Allele Symbol: Oprm1^tm1Jabl
• Allele Name: targeted mutation 1, Julie A Blendy
• Allele ID: MGI:3820121
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Oprm1^tm1Jabl/Oprm1^tm1Jabl	C57BL/6-Oprm1^tm1Jabl	MGI:3852355

Genotype
MGI:3852355

hm1

• Allelic Composition: Oprm1^tm1Jabl/Oprm1^tm1Jabl
• Genetic Background: C57BL/6-Oprm1^tm1Jabl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired behavioral response to morphine ( J:150840 )

• mice fail to exhibit hyperactivity after low doses of morphine as occurs in wild-type mice

impaired conditioned place preference behavior ( J:150840 )

• female but not male mice fail to show a conditioned place preference to morphine-paired environments

• naloxone-precipitated morphine withdrawal-induced place aversions are also reduced in female but not male mice

decreased chemically-elicited antinociception ( J:150840 )

• mice have a lower maximal possible effect of morphine in a hotplate test

decreased thermal nociceptive threshold ( J:150840 )

• mice have a reduced jump latency time when put on a 58-degree hotplate