Analysis Tools
homeostasis/metabolism
| N |
• cyclosporine A-treated mice exhibit normal hypertrophic cardiomyopathy
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Allele Symbol Allele Name Allele ID |
Postntm1Jmol targeted mutation 1, Jeffery D Molkentin MGI:3819350 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• cyclosporine A-treated mice exhibit normal hypertrophic cardiomyopathy
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• slightly
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• following induced myocardial infarct, mice exhibit less of an increase in the number of fibroblasts in the left ventricle compared to in wild-type mice
• following induced myocardial infarct, mice exhibit an increase in death during the first 10 days and a 2-fold increase in the rate of ventricular wall rupture but reduced fibrosis and overall size of scaring compared to similarly treated wild-type mice
• however, mice maintain better cardiac function compared to wild-type mice over the 8 weeks following the initial scar formation
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• following induced myocardial infarct, mice exhibit less of an increase in the number of fibroblasts in the left ventricle compared to in wild-type mice
• following induced myocardial infarct, mice exhibit an increase in death during the first 10 days and a 2-fold increase in the rate of ventricular wall rupture but reduced fibrosis and overall size of scaring compared to similarly treated wild-type mice
• however, mice maintain better cardiac function compared to wild-type mice over the 8 weeks following the initial scar formation
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• following transverse aortic constriction to induce pressure overload, mice exhibit less cardiac hypertrophy with reduced myocyte cross-section diameter and increased ventricular function after 8 weeks compared to similarly treated wild-type mice
• however, initial response during the first 2 weeks after pressure overload is normal
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• isolated fibroblasts exhibit reduced adhesion to neonatal cardiomyocytes compared to wild-type fibroblasts
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• as adults
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• cyclosporine A-treated mice exhibit reduced myocardial fibrosis than in similarly treated Myh6tm1Jse homozygotes
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• cyclosporine A-treated mice exhibit a 2.4-fold reduction in non-myocyte cell proliferation compared with similarly treated Myh6tm1Jse homozygotes but remains higher than in similarly treated wild-type mice
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• cyclosporine A-treated mice exhibit a modest, but not significantly, reduction in maximal left ventricular wall thickness compared with similarly treated Myh6tm1Jse homozygotes
• cyclosporine A-treated mice exhibit reduced myocardial fibrosis than in similarly treated Myh6tm1Jse homozygotes
• cyclosporine A-treated mice exhibit a 2.4-fold reduction in non-myocyte cell proliferation compared with similarly treated Myh6tm1Jse homozygotes but remains higher than in similarly treated wild-type mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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