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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Airetm2Mmat
targeted mutation 2, Mitsuru Matsumoto
MGI:3818933
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Airetm2Mmat/Airetm2Mmat involves: C57BL/6 * CBA MGI:3818934
ht2
 		Airetm1Mmat/Airetm2Mmat involves: C57BL/6 * CBA MGI:3818935
cx3
 		Airetm1Mmat/Airetm2Mmat
Tg(TcraTcrb)425Cbn/? 		involves: BALB/c * C57BL/6 * CBA MGI:3818937


Genotype
MGI:3818934
hm1
Allelic
Composition		 Airetm2Mmat/Airetm2Mmat
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Airetm2Mmat mutation (2 available); any Aire mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal thymus morphology ( J:141379 )
• GFP expressing cells are less complex in shape compared to GFP expressing cells in heterozygous mice
• GFP expressing cells tend to be localized uniformly within each medulla or enriched in the medulla center rather than enriched in the cortico-medullary junction as in heterozygous mice
absent Hassall's corpuscle ( J:141379 )
• Hassall's corpuscle-like structures are absent
abnormal thymus physiology ( J:141379 )
• the numbers of medullary thymic epithelial cells expressing involucrin are significantly reduced, especially at 4 and 8 weeks of age
autoimmune response ( J:141379 )
• display autoimmune pathology with onset at 4 to 6 weeks of age

hematopoietic system
abnormal thymus morphology ( J:141379 )
• GFP expressing cells are less complex in shape compared to GFP expressing cells in heterozygous mice
• GFP expressing cells tend to be localized uniformly within each medulla or enriched in the medulla center rather than enriched in the cortico-medullary junction as in heterozygous mice
absent Hassall's corpuscle ( J:141379 )
• Hassall's corpuscle-like structures are absent
abnormal thymus physiology ( J:141379 )
• the numbers of medullary thymic epithelial cells expressing involucrin are significantly reduced, especially at 4 and 8 weeks of age

endocrine/exocrine glands
abnormal thymus morphology ( J:141379 )
• GFP expressing cells are less complex in shape compared to GFP expressing cells in heterozygous mice
• GFP expressing cells tend to be localized uniformly within each medulla or enriched in the medulla center rather than enriched in the cortico-medullary junction as in heterozygous mice
absent Hassall's corpuscle ( J:141379 )
• Hassall's corpuscle-like structures are absent
abnormal thymus physiology ( J:141379 )
• the numbers of medullary thymic epithelial cells expressing involucrin are significantly reduced, especially at 4 and 8 weeks of age




Genotype
MGI:3818935
ht2
Allelic
Composition		 Airetm1Mmat/Airetm2Mmat
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Airetm1Mmat mutation (1 available); any Aire mutation (52 available)
Airetm2Mmat mutation (2 available); any Aire mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal thymus morphology ( J:141379 )
• GFP expressing cells are less complex in shape compared to GFP expressing cells in mice with one wild type allele
• distribution of GFP expressing cells is altered similar to mice homozygous for Airetm2Mmat

immune system
abnormal thymus morphology ( J:141379 )
• GFP expressing cells are less complex in shape compared to GFP expressing cells in mice with one wild type allele
• distribution of GFP expressing cells is altered similar to mice homozygous for Airetm2Mmat
autoimmune response ( J:141379 )
• display autoimmune pathology with onset at 4 to 6 weeks of age

endocrine/exocrine glands
abnormal thymus morphology ( J:141379 )
• GFP expressing cells are less complex in shape compared to GFP expressing cells in mice with one wild type allele
• distribution of GFP expressing cells is altered similar to mice homozygous for Airetm2Mmat




Genotype
MGI:3818937
cx3
Allelic
Composition		 Airetm1Mmat/Airetm2Mmat
Tg(TcraTcrb)425Cbn/?
Genetic
Background		 involves: BALB/c * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Airetm1Mmat mutation (1 available); any Aire mutation (52 available)
Airetm2Mmat mutation (2 available); any Aire mutation (52 available)
Tg(TcraTcrb)425Cbn mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:141379 )
N
• autoimmune pathology is absent unlike in mice not carrying Tg(TcraTcrb)425Cbn
abnormal thymus morphology ( J:141379 )
• GFP expressing cells are less complex in shape compared to GFP expressing cells in mice with one wild type allele
• distribution of GFP expressing cells is altered similar to mice homozygous for Airetm2Mmat

hematopoietic system
abnormal thymus morphology ( J:141379 )
• GFP expressing cells are less complex in shape compared to GFP expressing cells in mice with one wild type allele
• distribution of GFP expressing cells is altered similar to mice homozygous for Airetm2Mmat

endocrine/exocrine glands
abnormal thymus morphology ( J:141379 )
• GFP expressing cells are less complex in shape compared to GFP expressing cells in mice with one wild type allele
• distribution of GFP expressing cells is altered similar to mice homozygous for Airetm2Mmat




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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory