Phenotypes associated with this allele

• Allele Symbol: Txnip^tm1.1Rlee
• Allele Name: targeted mutation 1.1, Richard T Lee
• Allele ID: MGI:3818744
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Txnip^tm1.1Rlee/Txnip^tm1.1Rlee	involves: 129S4/SvJae	MGI:3818745

Genotype
MGI:3818745

hm1

• Allelic Composition: Txnip^tm1.1Rlee/Txnip^tm1.1Rlee
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:141487 )

N • no significant differences are detected in systolic blood pressure, left ventricular wall thickness, or left ventricular mass to tibial length ratio

abnormal heart left ventricle morphology ( J:141487 )

• echocardiography suggests a slight increase in left ventricular dimensions

increased cardiac muscle cell glucose uptake ( J:141487 )

• isolated perfused hearts from 17 to 20 week old mice show a dramatic increase in 2-deoxyglucose uptake during insulin free perfusion compared to controls

decreased ventricle muscle contractility ( J:141487 )

• echocardiography suggests a slight decrease in left ventricular fractional shortening

abnormal response of heart to induced stress ( J:141487 )

• decrease in pressure overload induced progressive hypertrophy during the early phase compared to controls

• however, in the late phase impairment of cardiac function is increased compared to controls

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:141487 )

N • unlike mice carrying Txnip^Hyplip1 serum levels of cholesterol and triglycerides are similar to controls

abnormal response of heart to induced stress ( J:141487 )

• decrease in pressure overload induced progressive hypertrophy during the early phase compared to controls

• however, in the late phase impairment of cardiac function is increased compared to controls

decreased circulating glucose level ( J:141487 )

• in fasting mice compared to controls

muscle

increased cardiac muscle cell glucose uptake ( J:141487 )

• isolated perfused hearts from 17 to 20 week old mice show a dramatic increase in 2-deoxyglucose uptake during insulin free perfusion compared to controls

decreased ventricle muscle contractility ( J:141487 )

• echocardiography suggests a slight decrease in left ventricular fractional shortening

cellular

increased cardiac muscle cell glucose uptake ( J:141487 )

• isolated perfused hearts from 17 to 20 week old mice show a dramatic increase in 2-deoxyglucose uptake during insulin free perfusion compared to controls