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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Txniptm1Rlee
targeted mutation 1, Richard T Lee
MGI:3818743
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Txniptm1Rlee/Txniptm1Rlee
Tg(Myh6-cre/Esr1*)1Jmk/0
involves: 129S4/SvJae * FVB/N MGI:3818746


Genotype
MGI:3818746
cn1
Allelic
Composition
Txniptm1Rlee/Txniptm1Rlee
Tg(Myh6-cre/Esr1*)1Jmk/0
Genetic
Background
involves: 129S4/SvJae * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6-cre/Esr1*)1Jmk mutation (2 available)
Txniptm1Rlee mutation (1 available); any Txnip mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• robust increase in glucose uptake in 4-hydroxytamoxifen treated mice compared to controls
• mice treated with 4-hydroxytamoxifen to induce recombination display a decrease in pressure overload induced progressive hypertrophy during the early phase compared to controls

muscle
• robust increase in glucose uptake in 4-hydroxytamoxifen treated mice compared to controls

homeostasis/metabolism
• mice treated with 4-hydroxytamoxifen to induce recombination display a decrease in pressure overload induced progressive hypertrophy during the early phase compared to controls

cellular
• robust increase in glucose uptake in 4-hydroxytamoxifen treated mice compared to controls





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory