Mouse Genome Informatics
cn1
    Hgstm2Tkh/Hgstm2Tkh
Tg(Syn1-cre)671Jxm/0

involves: C57BL/6 * CBA * SJL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
reproductive system

nervous system
• the number of neurons undergoing apoptosis in the CA3 region is increased compared to in wild-type mice
• at 5 weeks of age, mice exhibit a loss of pyramidal neurons in the CA3 region that progressively worsens with age unlike in wild-type mice
• however, the numbers of pyramidal cells in the CA1 region and mossy fiber attachments are normal
• pyramidal neuron loss is due to increased apoptosis of cells

behavior/neurological
• mice exhibit increased time immobilized during a swim test despite normal muscle strength
• mice exhibit a reduced latency to entering in a dark box compared to wild-type mice in a passive avoidance test

growth/size
• begining at 3 weeks
• by 8 weeks of age, mice cease to gain weight unlike wild-type mice

cellular
• the number of neurons undergoing apoptosis in the CA3 region is increased compared to in wild-type mice