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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Hgstm2Tkh
targeted mutation 2, Nobuyuki Tanaka
MGI:3818694
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Hgstm2Tkh/Hgstm2Tkh
Tg(Syn1-cre)671Jxm/0
involves: C57BL/6 * CBA * SJL MGI:3818706


Genotype
MGI:3818706
cn1
Allelic
Composition
Hgstm2Tkh/Hgstm2Tkh
Tg(Syn1-cre)671Jxm/0
Genetic
Background
involves: C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hgstm2Tkh mutation (0 available); any Hgs mutation (21 available)
Tg(Syn1-cre)671Jxm mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system

nervous system
• the number of neurons undergoing apoptosis in the CA3 region is increased compared to in wild-type mice
• at 5 weeks of age, mice exhibit a loss of pyramidal neurons in the CA3 region that progressively worsens with age unlike in wild-type mice
• however, the numbers of pyramidal cells in the CA1 region and mossy fiber attachments are normal
• pyramidal neuron loss is due to increased apoptosis of cells

behavior/neurological
• mice exhibit a reduced latency to entering in a dark box compared to wild-type mice in a passive avoidance test
• mice exhibit increased time immobilized during a swim test despite normal muscle strength

growth/size/body
• begining at 3 weeks
• by 8 weeks of age, mice cease to gain weight unlike wild-type mice

cellular
• the number of neurons undergoing apoptosis in the CA3 region is increased compared to in wild-type mice





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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory