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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Strctm1Ugds
targeted mutation 1, Unite de Genetique des Deficits Sensoriels
MGI:3818633
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Strctm1Ugds/Strctm1Ugds involves: 129S2/SvPas * BALB/c * C57BL/6 * C57BL/6J MGI:3818653


Genotype
MGI:3818653
hm1
Allelic
Composition
Strctm1Ugds/Strctm1Ugds
Genetic
Background
involves: 129S2/SvPas * BALB/c * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Strctm1Ugds mutation (0 available); any Strc mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
• hair-bundle imprints corresponding to the anchoring points of the tallest outer hair cell stereocilia are absent
• the tops of the stereocilia rows in all outer hair cells, but not inner hair cells, are not as clearly aligned as in wild-type mice
• at P14, simultaneous masking of CAP is weakened compared to in wild-type mice
• at P60, mice exhibit an increase in compound auditory potential (CAP) threshold compared to in wild-type mice due to loss of functional mechanoelectrical transducer channels
• from P15 to P60, the amplitude of cochlear microphonic response decreased compared to in wild-type mice indicating a loss of mechanoelectrical transducer channels
• however, cochlear microphonic waves have the same phase as in wild-type mice
• up to 80 db from P14 onward
• from P15

nervous system
• hair-bundle imprints corresponding to the anchoring points of the tallest outer hair cell stereocilia are absent
• the tops of the stereocilia rows in all outer hair cells, but not inner hair cells, are not as clearly aligned as in wild-type mice
• from P15 to P60, the amplitude of cochlear microphonic response decreased compared to in wild-type mice indicating a loss of mechanoelectrical transducer channels
• however, cochlear microphonic waves have the same phase as in wild-type mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Deafness, Autosomal Recessive 16; DFNB16 603720 J:141421





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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory