About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Atg16l1Gt(XR0164)Wtsi
gene trap XR0164, Wellcome Trust Sanger Institute
MGI:3818575
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Atg16l1Gt(XR0164)Wtsi/Atg16l1Gt(XR0164)Wtsi involves: 129P2/OlaHsd * C57BL/6 MGI:3818604


Genotype
MGI:3818604
hm1
Allelic
Composition
Atg16l1Gt(XR0164)Wtsi/Atg16l1Gt(XR0164)Wtsi
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg16l1Gt(XR0164)Wtsi mutation (0 available); any Atg16l1 mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• aberrant, disorganized granules as well as decreased granule numbers are observed in these mice
• virtually all Paneth cells have lysozyme localized throughout the cell instead of being discretely packaged within vesicles
• Paneth cells also have degenerating mitochondria, loss of granules and the frequent absence of apical microvilli
• adjacent crypt lumen often contains intact Paneth granules and cytoplasm, which is a phenomenon not observed in wild-type controls

homeostasis/metabolism
• autophagy by the ileal epithelium and thymocytes is severely reduced in these mice

cellular
• autophagy by the ileal epithelium and thymocytes is severely reduced in these mice

endocrine/exocrine glands
• aberrant, disorganized granules as well as decreased granule numbers are observed in these mice
• virtually all Paneth cells have lysozyme localized throughout the cell instead of being discretely packaged within vesicles
• Paneth cells also have degenerating mitochondria, loss of granules and the frequent absence of apical microvilli
• adjacent crypt lumen often contains intact Paneth granules and cytoplasm, which is a phenomenon not observed in wild-type controls

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
inflammatory bowel disease 10 DOID:0110885 OMIM:611081
J:141419





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory