Phenotypes associated with this allele

• Allele Symbol: Senp1^Gt(XG001)Byg
• Allele Name: gene trap XG001, BayGenomics
• Allele ID: MGI:3818522
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Senp1^Gt(XG001)Byg/Senp1^Gt(XG001)Byg	involves: 129P2/OlaHsd	MGI:3818543

Genotype
MGI:3818543

hm1

• Allelic Composition: Senp1^Gt(XG001)Byg/Senp1^Gt(XG001)Byg
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:141453 )

• most mice die between E13 and E15

hematopoietic system

hematopoietic system phenotype ( J:141453 )

N • despite a reduction in erythroid progenitors, mice exhibit normal numbers of granulocyte-macrophage and pluripotent hematopoietic stem cells

abnormal erythropoiesis ( J:141453 )

• mice exhibit fewer nucleated cells in the fetal livers and a decrease in the number or erythropoietic foci compared to in wild-type mice

anemia ( J:141453 )

• at E15.5, mice exhibit severe fetal anemia

decreased erythroid progenitor cell number ( J:141453 )

• at E13.5, the number of Ter-119+ erythroid precursors in the fetal liver is decreased compared to in wild-type mice due to apoptosis

• at E13.5, fetal liver cells produce 40% fewer erythroid colony-forming unit compared to wild-type cells

• however, the number of erythroid burst-forming unit are normal and supplementing medium with erythropoietin prevents the apoptosis of erythrocyte progenitor cells

decreased erythrocyte cell number ( J:141453 )

• at E15.5, mice exhibit 75% fewer erythrocytes compared to in wild-type or heterozygous mice

growth/size/body

decreased fetal size ( J:141453 )

• at E15.5

liver/biliary system

small liver ( J:141453 )

• fetal liver size is smaller than normal

integument

pallor ( J:141453 )

• at E15.5