Analysis Tools
mortality/aging
|
• lethality occurs before E3.5
|
|
Allele Symbol Allele Name Allele ID |
Cdk1tm1(Cdk2)Kald targeted mutation 1, Philipp Kaldis MGI:3818306 |
||||||||||||||||
| Summary |
3 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• lethality occurs before E3.5
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice are viable and fertile
• mice pass on the mutant allele to descendents
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
 |
• oocytes fail to develop in the atrophied ovaries of these mice
|
 |
• there is extensive apoptosis of male germ cells in 20-day old males
|
|
|
• no follicles are observed in the ovaries of 90-day old mice
|
|
|
• ovaries of adult female mice are only half the size of controls
|
|
|
• round spermatids are absent in the testis of 20-day old males
|
|
|
• spermatocyte numbers are depleted in the testes of 3-month old mice
• there is an increase in the number of apoptotic spermatocytes in the testes of 10-day old mice
|
|
|
• a greater number of spermatocytes reach the pachytene stage of meiosis than controls
|
|
|
• the seminiferous tubules are much smaller in 3-month old males
|
|
|
• testis are 20-30% smaller than controls at twenty days of age
• testis of adult males are only half the size of controls
|
|
• both male and female mice are sterile
|
|
|
• no follicles are observed in the ovaries of 90-day old mice
|
|
|
• ovaries of adult female mice are only half the size of controls
|
|
|
• the seminiferous tubules are much smaller in 3-month old males
|
|
|
• testis are 20-30% smaller than controls at twenty days of age
• testis of adult males are only half the size of controls
|
|
|
• oocytes fail to develop in the atrophied ovaries of these mice
|
|
|
• round spermatids are absent in the testis of 20-day old males
|
|
|
• spermatocyte numbers are depleted in the testes of 3-month old mice
• there is an increase in the number of apoptotic spermatocytes in the testes of 10-day old mice
|
|
|
• there is extensive apoptosis of male germ cells in 20-day old males
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 04/16/2024 MGI 6.23 |
|
|
|
||