Phenotypes associated with this allele
mortality/aging
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• induction of cre-recombinase expression at E11.5 leads to death of the animal during the perinatal period
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nervous system
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• the number of neurons expressing TrpVI and TrpM8 are markedly decreased in the dorsal root ganglion of E18.5 embryos that have had cre-recombinase induced at E11.5
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mortality/aging
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• mice die within a few hours of birth
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nervous system
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• cutaneous branch of the ventral ramus is absent in E14.5 embryos
• innervation of the distal limbs at E14.5 confirmed a nearly complete loss of fine cutaneous sensory fibers with only a single sensory branch innervating one side of digits 1, 2 and 5 in both the forelimb and hindlimb
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• there is an increased rate of apoptosis within the trigeminal ganglia of E11.5 and E12.5 embryos
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• the dorsal root ganglion (DRG) of E12.5 embryos do not express Isl1 protein
• TrkA+ neurons are lower in number starting at E12.5 and by E14.5 are less than one-third of what is found in controls
• TrkB+ neurons are also lower in number starting at E12.5 and are markedly reduced at E14.5 and birth
• TrkC+ neurons do not appear until E12.5, a delay of two days compared to controls
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• the DRG of E14.5 embryos is markedly smaller than controls with a smaller number neurons found within the ganglion
• an increased rate of apoptosis is noted in the E12.5 DRG
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behavior/neurological
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• mice have a reduced response to a mild noxious stimulus that was applied to the skin of the trunk or limbs
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl1tm2.1Sev mutation
(0 available);
any
Isl1 mutation
(33 available)
Isl1tm2Sev mutation
(1 available);
any
Isl1 mutation
(33 available)
Tg(Hoxb6-cre)#Mku mutation
(1 available)
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limbs/digits/tail
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• expression analysis indicates proximal patterning defects in the hindlimb buds
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• variable severity of hindlimb digit loss
• almost half of mice display hindlimbs with only 3 digits
• less severely affected mice develop 4 hindlimb digits, lacking the posterior digit 5
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• only a single zeugopodal element, likely corresponding to the tibia, is present in most mice with 1 - 3 digits on the hindlimb
• mice with 4 digits on the hindlimb show more variability in zeugopodal defects
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• in severely affected mice
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embryo
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• expression analysis indicates proximal patterning defects in the hindlimb buds
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skeleton