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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Batf3tm1Kmm
targeted mutation 1, Kenneth M Murphy
MGI:3817232
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Batf3tm1Kmm/Batf3tm1Kmm involves: 129S6/SvEvTac MGI:5313304
hm2
Batf3tm1Kmm/Batf3tm1Kmm involves: 129S6/SvEvTac * BALB/cJ MGI:3817249
cx3
Batf3tm1Kmm/Batf3tm1Kmm
Id2tm1Gtbz/Id2tm1Gtbz
B6.Cg-Batf3tm1Kmm Id2tm1Gtbz MGI:5486201


Genotype
MGI:5313304
hm1
Allelic
Composition
Batf3tm1Kmm/Batf3tm1Kmm
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Batf3tm1Kmm mutation (4 available); any Batf3 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• homozygotes retain an enhanced antibody response to anti-Clec9a coupled antigen
• reduced cytotoxic T cell response to anti-Clec9a coupled antigen

hematopoietic system
• reduced cytotoxic T cell response to anti-Clec9a coupled antigen




Genotype
MGI:3817249
hm2
Allelic
Composition
Batf3tm1Kmm/Batf3tm1Kmm
Genetic
Background
involves: 129S6/SvEvTac * BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Batf3tm1Kmm mutation (4 available); any Batf3 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice lack CD8a+ dendritic cell subsets
• bone marrow chimera experiments indicate a lack of CD8a+ DCs is due to a cell-intrinsic effect of the mutant locus
• in vitro bone marrow differentiation cultures fail to generate CD24+ Sirp-alpha- DCs that are similar to CD8a+ DC
• mice lack splenic CD11chiCD8a+DEC205+ dendritic cells
• mice have a loss of CD11chiCD11bdull DCs and CD11chi CD8a+CD24+ DCs
• mice have normal populations of CD4+ and CD8a-CD4- conventional DC subsets
• lymph nodes and thymi lack CD8a+ DC subsets
• CD103-+DEC205+CD8a-CD11blo/- dermal DC numbers are reduced 5-fold in draining lymph nodes of the skin
• mice fail to develop West Nile Virus (WNV)-specific memory CD8+ T cells after infection with the virus
• the number of CD8+CD44hiCD62Llowcells memory cells is about half-that of wild-type mice before infection and is five-fold less after infection
• transplanted syngenic fibrosarcomas grow in size instead of being reapidly rejected as happens in control mice
• CD8+ T cells from mice infected with West Nile virus (WNV) have defective IFN-gamma secretion when cultured with WNV-peptide
• bone marrow chimera studies demonstrate that defective cytolytic activity is not intrinsic to the CD8+ T cells but rather defective dendritic cell function
• infiltrating CD8+ T cells fail to infiltrate transplanted syngenic tumors
• CD8+ T cells from mice infected with West Nile virus (WNV) have defective killing of WNV peptide-loaded target cells
• conventional DCs fail to secrete IL-12 after TL3 stimulation but have normal responses to TLR4 and TLR9 stimulation
• conventional DCs are unable to cross-present (i.e. take up protein, process into peptide and present) ovalbumin antigen to ova-specific CD8+ T cells

hematopoietic system
• mice lack CD8a+ dendritic cell subsets
• bone marrow chimera experiments indicate a lack of CD8a+ DCs is due to a cell-intrinsic effect of the mutant locus
• in vitro bone marrow differentiation cultures fail to generate CD24+ Sirp-alpha- DCs that are similar to CD8a+ DC
• mice lack splenic CD11chiCD8a+DEC205+ dendritic cells
• mice have a loss of CD11chiCD11bdull DCs and CD11chi CD8a+CD24+ DCs
• mice have normal populations of CD4+ and CD8a-CD4- conventional DC subsets
• lymph nodes and thymi lack CD8a+ DC subsets
• CD103-+DEC205+CD8a-CD11blo/- dermal DC numbers are reduced 5-fold in draining lymph nodes of the skin
• mice fail to develop West Nile Virus (WNV)-specific memory CD8+ T cells after infection with the virus
• the number of CD8+CD44hiCD62Llowcells memory cells is about half-that of wild-type mice before infection and is five-fold less after infection
• CD8+ T cells from mice infected with West Nile virus (WNV) have defective IFN-gamma secretion when cultured with WNV-peptide
• bone marrow chimera studies demonstrate that defective cytolytic activity is not intrinsic to the CD8+ T cells but rather defective dendritic cell function
• infiltrating CD8+ T cells fail to infiltrate transplanted syngenic tumors
• CD8+ T cells from mice infected with West Nile virus (WNV) have defective killing of WNV peptide-loaded target cells

cellular
• mice lack CD8a+ dendritic cell subsets
• bone marrow chimera experiments indicate a lack of CD8a+ DCs is due to a cell-intrinsic effect of the mutant locus
• in vitro bone marrow differentiation cultures fail to generate CD24+ Sirp-alpha- DCs that are similar to CD8a+ DC




Genotype
MGI:5486201
cx3
Allelic
Composition
Batf3tm1Kmm/Batf3tm1Kmm
Id2tm1Gtbz/Id2tm1Gtbz
Genetic
Background
B6.Cg-Batf3tm1Kmm Id2tm1Gtbz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Batf3tm1Kmm mutation (4 available); any Batf3 mutation (17 available)
Id2tm1Gtbz mutation (0 available); any Id2 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• in reconstitution assays, CD8alpha+ dendritic cells generate from transplanted bone marrow cells fail to survive long-term
• CD8alpha+ dendritic cells exhibit impaired cell-associated cross-presentation compared with control cells
• however, cells exhibit normal soluble cross-presentation and cell-associated antigen cross-presentation during GVHD or HSV-1 viral antigens





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/19/2021
MGI 6.17
The Jackson Laboratory