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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nr1i3tm1(NR1I3)Arte
targeted mutation 1, TaconicArtemis
MGI:3815103
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Nr1i3tm1(NR1I3)Arte/Nr1i3tm1(NR1I3)Arte involves: C57BL/6 MGI:3815125


Genotype
MGI:3815125
hm1
Allelic
Composition
Nr1i3tm1(NR1I3)Arte/Nr1i3tm1(NR1I3)Arte
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr1i3tm1(NR1I3)Arte mutation (2 available); any Nr1i3 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice exhibit normal survival

homeostasis/metabolism
• mice exhibit decreased induction of Cyp2b10 and Cyp3a11 expression TCPOBOP (1,4-bis[2-(3,5-dichloropyridyloxy)]benzene) compared to similarly treated wild-type mice
• mice exhibit increased induction of Cyp2b10 and Cyp3a11 expression following treatment with CITCO (6-(4-chlorophenyl)imidazo-[2,1-b][1,3]thiazole-5-carbaldehydeO-(3,4-dichloro-benzyl)oxime) compared to similarly treated wild-type mice
• following treatment with CITCO (6-(4-chlorophenyl)imidazo-[2,1-b][1,3]thiazole-5-carbaldehydeO-(3,4-dichloro-benzyl)oxime), mice exhibit increased clearance of midazolam and buproprion compared to similarly treated wild-type mice

liver/biliary system
N
• mice exhibit normal liver histology

reproductive system
N
• mice exhibit normal fertility





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory