Analysis Tools
cardiovascular system
hypertension
(
J:140705
)
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• mice develop age-dependent hypertension beginning at week 7
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• mice exhibit reduced endothelium-dependent vasorelaxation compared to wild-type mice
• mice exhibit an impaired relaxation response to methacholine following constriction with phenylephrine compared to in wild-type mice
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homeostasis/metabolism
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• in male mice, L-cysteine levels are 0.8 times the levels found in wild-type mice
• female mice exhibit a decrease in plasma L-cysteine levels compared to wild-type mice
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• in male mice, plasma homocysteine levels are 18 times the levels found in wild-type mice
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• mice exhibit an impaired relaxation response to methacholine following constriction with phenylephrine compared to in wild-type mice
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• treatment with NaHS reduces systolic blood pressure to a greater extent than in wild-type mice
• treatment with H2S causes more relaxation of mesenteric arteries than in wild-type mice
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renal/urinary system
| N |
• despite increase in blood pressure, mice exhibit normal kidney morphology and function
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muscle
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• mice exhibit reduced endothelium-dependent vasorelaxation compared to wild-type mice
• mice exhibit an impaired relaxation response to methacholine following constriction with phenylephrine compared to in wild-type mice
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