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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Six3tm4(cre/ERT2)Gco
targeted mutation 4, Guillermo Oliver
MGI:3814875
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Six3tm4(cre/ERT2)Gco/Six3+ involves: 129S1/Sv * C57BL/6 MGI:3814906


Genotype
MGI:3814906
ht1
Allelic
Composition
Six3tm4(cre/ERT2)Gco/Six3+
Genetic
Background
involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Six3tm4(cre/ERT2)Gco mutation (0 available); any Six3 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• Background Sensitivity: 16% display a phenotype typical of holoprosencephaly after one backcross to C57BL/6
• Background Sensitivity: after two additional backcrosses to C57BL/6, 85% show a holoprosencephaly phenotype

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
holoprosencephaly 2 DOID:0110872 OMIM:157170
J:140315





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/22/2022
MGI 6.21
The Jackson Laboratory