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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gt(ROSA)26Sortm2(Cd74*)Awai
targeted mutation 2, Ari Waisman
MGI:3814853
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Cd19tm1(cre)Cgn/Cd19+
Gt(ROSA)26Sortm2(Cd74*)Awai/Gt(ROSA)26Sor+
involves: 129P2/OlaHsd * C57BL/6 MGI:3814891
cn2
Cd19tm1(cre)Cgn/Cd19+
Gt(ROSA)26Sortm2(Cd74*)Awai/Gt(ROSA)26Sor+
Il10tm1Roer/Il10tm1Roer
involves: 129P2/OlaHsd * C57BL/6 MGI:3814893


Genotype
MGI:3814891
cn1
Allelic
Composition
Cd19tm1(cre)Cgn/Cd19+
Gt(ROSA)26Sortm2(Cd74*)Awai/Gt(ROSA)26Sor+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (8 available); any Cd19 mutation (15 available)
Gt(ROSA)26Sortm2(Cd74*)Awai mutation (0 available); any Gt(ROSA)26Sor mutation (523 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• B cells, but not dendritic cells or macrophages, are capable of inducing proliferation of CD4+ T cells containing Tg(Tcra2D2,Tcrb2D2)1Kuch in vitro unlike wild-type cells
• unlike in vitro, when CD4+ T cells containing Tg(Tcra2D2,Tcrb2D2)1Kuch are transferred into mice they fail to exhibit proliferation and instead undergo cell death
• mice are capable of inducing proliferation of memory T cells expressing Tg(Tcra2D2,Tcrb2D2)1Kuch unlike wild type mice
• mice are capable of inducing proliferation of Tg(Tcra2D2,Tcrb2D2)1Kuch T cells also deficient in Pdcd1 (Pdcd1tm1Hon) up to 71% or following treatment with anti-CTLA-4 antibodies up to 79% and proliferation is increased to 97% when both are used
• B cells induce peripheral tolerance by sensitizing T cells to antigen induced cell death in adoptive transfer experiments
• mice are resistant to direct and passive MOG-induced experimental autoimmune encephalomyelitis (EAE) and can confer some resistance upon adoptive transfer of B cells into wild-type micemice are resistant to direct and passive MOG-induced experimental encephalomyelitis (EAE) and can confer some resistance upon adoptive transfer of B cells into wild-type mice
• resistance to EAE is not affected by depletion of T regulatory cells
• however, mice inoculated with C57BL/6 spinal cord fluid develop EAE

hematopoietic system
• B cells, but not dendritic cells or macrophages, are capable of inducing proliferation of CD4+ T cells containing Tg(Tcra2D2,Tcrb2D2)1Kuch in vitro unlike wild-type cells
• unlike in vitro, when CD4+ T cells containing Tg(Tcra2D2,Tcrb2D2)1Kuch are transferred into mice they fail to exhibit proliferation and instead undergo cell death
• mice are capable of inducing proliferation of memory T cells expressing Tg(Tcra2D2,Tcrb2D2)1Kuch unlike wild type mice
• mice are capable of inducing proliferation of Tg(Tcra2D2,Tcrb2D2)1Kuch T cells also deficient in Pdcd1 (Pdcd1tm1Hon) up to 71% or following treatment with anti-CTLA-4 antibodies up to 79% and proliferation is increased to 97% when both are used
• B cells induce peripheral tolerance by sensitizing T cells to antigen induced cell death in adoptive transfer experiments




Genotype
MGI:3814893
cn2
Allelic
Composition
Cd19tm1(cre)Cgn/Cd19+
Gt(ROSA)26Sortm2(Cd74*)Awai/Gt(ROSA)26Sor+
Il10tm1Roer/Il10tm1Roer
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (8 available); any Cd19 mutation (15 available)
Gt(ROSA)26Sortm2(Cd74*)Awai mutation (0 available); any Gt(ROSA)26Sor mutation (523 available)
Il10tm1Roer mutation (0 available); any Il10 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• unlike in vitro, when CD4+ T cells containing Tg(Tcra2D2,Tcrb2D2)1Kuch are transferred into mice they fail to exhibit proliferation
• mice are resistant to direct and passive MOG-induced experimental autoimmune encephalomyelitis

hematopoietic system
• unlike in vitro, when CD4+ T cells containing Tg(Tcra2D2,Tcrb2D2)1Kuch are transferred into mice they fail to exhibit proliferation





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory