behavior/neurological

abnormal spatial learning ( J:71821 )

• mice exhibit learning in a Morris water maze compared to wild-type mice with longer escape latencies in the first acquisition sessions

• mice are not effective at discriminating previously trained quadrants

abnormal spatial reference memory ( J:71821 )

• in a repeated acquisition version of the Morris water maze, mice display increased escape latencies and distance traveled compared to wild-type mice

Mouse Models of Human Disease		OMIM ID	Ref(s)
Down Syndrome		190685	J:71821