Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf19Gt(OST294987)Lex mutation
(1 available);
any
Tnfrsf19 mutation
(35 available)
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cardiovascular system
reproductive system
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N |
• mice are fertile with normal nursing behavior, normal numbers of nipples and normal mammary gland development
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craniofacial
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N |
• mice exhibit normal tooth number and shape
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integument
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N |
• mice exhibit normal skin and hair with normal sweating ability
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nervous system
craniofacial
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• mice exhibit one incisor and three molars in each quarter of the jaw unlike in wild-type mice
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• some mice are missing the incisors
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• molars exhibit a reduced number of cusps compared to in wild-type mice
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• some mice exhibit a loss of the third molar
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skeleton
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• mice exhibit one incisor and three molars in each quarter of the jaw unlike in wild-type mice
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• some mice are missing the incisors
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• molars exhibit a reduced number of cusps compared to in wild-type mice
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• some mice exhibit a loss of the third molar
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endocrine/exocrine glands
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• mice produce no sweat and lack sweat glands as in EdaTa homozygotes
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integument
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• mice produce no sweat and lack sweat glands as in EdaTa homozygotes
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• mice possess only awl hairs
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• mice exhibit a bald patch at the top of the vertex that is expanded in some mice into the neck and extends laterally in a symmetrical pattern
• alopecia is evident at the time of first hair emergence and not associated with sex, age or hair cycling
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• compared to in EdaTa homozygotes
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• mice lack primary and secondary hair follicles
• however, treatment with Eda-A1 restores secondary hair follicles
• at E18, follicle development in the center of the cranium is absent
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growth/size/body
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• mice exhibit one incisor and three molars in each quarter of the jaw unlike in wild-type mice
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• some mice are missing the incisors
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• molars exhibit a reduced number of cusps compared to in wild-type mice
|
|
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• some mice exhibit a loss of the third molar
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craniofacial
 |
• mice exhibit one incisor and three molars in each quarter of the jaw unlike in wild-type mice
|
|
|
• some mice are missing the incisors
|
|
|
• molars exhibit a reduced number of cusps compared to in wild-type mice
|
|
|
• some mice exhibit a loss of the third molar
|
skeleton
|
|
• mice exhibit one incisor and three molars in each quarter of the jaw unlike in wild-type mice
|
|
|
• some mice are missing the incisors
|
|
|
• molars exhibit a reduced number of cusps compared to in wild-type mice
|
|
|
• some mice exhibit a loss of the third molar
|
endocrine/exocrine glands
|
|
• mice produce no sweat and lack sweat glands as in EdaTa homozygotes
|
integument
|
|
• mice produce no sweat and lack sweat glands as in EdaTa homozygotes
|
|
|
• mice possess only awl hairs
|
|
|
• mice exhibit a bald patch at the top of the vertex that is expanded in some mice into the neck and extends laterally in a symmetrical pattern
• alopecia is evident at the time of first hair emergence and not associated with sex, age or hair cycling
|
|
|
• compared to in EdaTa homozygotes
|
|
|
• mice lack primary and secondary hair follicles
• at E18, follicle development in the center of the cranium is absent
• however, treatment with Eda-A1 restores secondary hair follicles
|
growth/size/body
|
|
• mice exhibit one incisor and three molars in each quarter of the jaw unlike in wild-type mice
|
|
|
• some mice are missing the incisors
|
|
|
• molars exhibit a reduced number of cusps compared to in wild-type mice
|
|
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• some mice exhibit a loss of the third molar
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Analysis Tools