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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(SV40-Igk4C8)L1Hon
transgene insertion L1, Tasuku Honjo
MGI:3813630
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Tg(SV40-Igh-64C8)H3Hon/0
Tg(SV40-Igk4C8)L1Hon/0
involves: C57BL/6 MGI:3813631


Genotype
MGI:3813631
cx1
Allelic
Composition
Tg(SV40-Igh-64C8)H3Hon/0
Tg(SV40-Igk4C8)L1Hon/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
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phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• idiotype positive Ly-1 B cells escape clonal deletion
• about 5% of mice develop anemia with an enormous accumulation of agglutinated erythrocytes
• tolerant mice become anemic following injection of LPS
• inversely correlated with autoantibody levels
• mice fall within 3 categories; those with anemia (hematocrit less than 30%, 5% of mice), those that are intermediate (hematocrit between 30% and 40%, 44% of mice) and those that are tolerant (hematocrit above 40%, 51% of mice)
• general decrease in idiotype positive B cells and large decrease in the ratio of B cells to pre B cells in the spleen and lymph node
• the degree of deletion of idiotype positive B cells varies among individuals
• remaining B cells are anergized
• no difference in B cell number or the ratio of B cells to pre B cells is seen in the bone marrow
• red blood cell half life is decreased in mice in the intermediate group

immune system
• idiotype positive Ly-1 B cells escape clonal deletion
• general decrease in idiotype positive B cells and large decrease in the ratio of B cells to pre B cells in the spleen and lymph node
• the degree of deletion of idiotype positive B cells varies among individuals
• remaining B cells are anergized
• no difference in B cell number or the ratio of B cells to pre B cells is seen in the bone marrow
• considerable amounts of autoantibody are found associated with erythrocytes
• the amount of autoantibody present varies over a 2-log range

Mouse Models of Human Disease
OMIM ID Ref(s)
Anemia, Autoimmune Hemolytic 205700 J:139864





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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory