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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pkd1tm3.1Jzh
targeted mutation 3.1, Jing Zhou
MGI:3811234
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Pkd1tm3.1Jzh/Pkd1tm3.1Jzh involves: 129P2/OlaHsd * C57BL/6 MGI:3811280


Genotype
MGI:3811280
hm1
Allelic
Composition
Pkd1tm3.1Jzh/Pkd1tm3.1Jzh
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkd1tm3.1Jzh mutation (0 available); any Pkd1 mutation (153 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• the 50% of mice that survive until birth die shortly thereafter
• only half the expected number of homozygotes survive are born at birth

homeostasis/metabolism
• systemic edema is noted in mice that have survived until birth
• is noted in mice that have survived until birth

renal/urinary system
• kidney cysts are first detectable in embryos at E15.5
• new born mice have polycystic kidneys with large cysts visibly disrupting the kidney architecture

growth/size/body
• kidney cysts are first detectable in embryos at E15.5
• new born mice have polycystic kidneys with large cysts visibly disrupting the kidney architecture

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
polycystic kidney disease 1 DOID:0110858 OMIM:173900
J:140012





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory