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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Olig2tm2(TVA,cre)Rth
targeted mutation 2, David H Rowitch
MGI:3810299
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc
Olig2tm2(TVA,cre)Rth/Olig2+
involves: 129 * 129X1/SvJ MGI:3810318
cn2
Prrc2atm1Fcw/Prrc2atm1Fcw
Olig2tm2(TVA,cre)Rth/Olig2+
involves: 129 * C57BL/6 MGI:6724442
cn3
Cspg4tm1Ychan/Cspg4tm1Ychan
Olig2tm2(TVA,cre)Rth/Olig2+
involves: 129 * C57BL/6N MGI:5427427
cn4
Gt(ROSA)26Sortm1(Hoxa2)Fmr/Gt(ROSA)26Sor+
Olig2tm2(TVA,cre)Rth/Olig2+
involves: 129P2/OlaHsd MGI:5470400
cn5
Myrftm1Barr/Myrftm1Barr
Olig2tm2(TVA,cre)Rth/Olig2+
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 MGI:3852094


Genotype
MGI:3810318
cn1
Allelic
Composition
Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc
Olig2tm2(TVA,cre)Rth/Olig2+
Genetic
Background
involves: 129 * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Smo/EYFP)Amc mutation (1 available); any Gt(ROSA)26Sor mutation (745 available)
Olig2tm2(TVA,cre)Rth mutation (1 available); any Olig2 mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice develop focal medulloblastomas localized to the posterior-lateral lobes and have mean survival of 33 days

mortality/aging
• mice survive 33 days

neoplasm
• mice develop focal medulloblastomas localized to the posterior-lateral lobes and have mean survival of 33 days

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
medulloblastoma DOID:0050902 OMIM:155255
J:139574




Genotype
MGI:6724442
cn2
Allelic
Composition
Prrc2atm1Fcw/Prrc2atm1Fcw
Olig2tm2(TVA,cre)Rth/Olig2+
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Olig2tm2(TVA,cre)Rth mutation (1 available); any Olig2 mutation (36 available)
Prrc2atm1Fcw mutation (0 available); any Prrc2a mutation (48 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

nervous system
N
• mice exhibit normal ventral neuron numbers in the spinal cord
• however, neuron number is normal
• increased signal density on MRIs
• hypomyelination in the corpus callosum at 4 weeks of age and in adults

growth/size/body

behavior/neurological




Genotype
MGI:5427427
cn3
Allelic
Composition
Cspg4tm1Ychan/Cspg4tm1Ychan
Olig2tm2(TVA,cre)Rth/Olig2+
Genetic
Background
involves: 129 * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cspg4tm1Ychan mutation (0 available); any Cspg4 mutation (73 available)
Olig2tm2(TVA,cre)Rth mutation (1 available); any Olig2 mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue

growth/size/body




Genotype
MGI:5470400
cn4
Allelic
Composition
Gt(ROSA)26Sortm1(Hoxa2)Fmr/Gt(ROSA)26Sor+
Olig2tm2(TVA,cre)Rth/Olig2+
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Hoxa2)Fmr mutation (0 available); any Gt(ROSA)26Sor mutation (745 available)
Olig2tm2(TVA,cre)Rth mutation (1 available); any Olig2 mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• 2-fold decrease in ventral oligodendrogenesis in the prepontine (rhombomere 2- and 3-derived) and pontine (rhombomere 4-derived) territories compared with controls
• however, migration of oligodendrite progenitor cells is normal
• decrease in ventral oligodendrogenesis in the prepontine (rhombomere 2- and 3-derived) and pontine (rhombomere 4-derived) territories at E13.5 due to reduced proliferation
• however, ventricular progenitors are recovered following additional cell cycle before differentiation




Genotype
MGI:3852094
cn5
Allelic
Composition
Myrftm1Barr/Myrftm1Barr
Olig2tm2(TVA,cre)Rth/Olig2+
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myrftm1Barr mutation (1 available); any Myrf mutation (81 available)
Olig2tm2(TVA,cre)Rth mutation (1 available); any Olig2 mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die during third postnatal week

behavior/neurological
• severe tremors are observed around P11
• observed around P11
• develop after P10

nervous system
N
• gross CNS architecture is normal
• motor neuron population in spinal cord is intact
• peripheral nerves are fully myelinated
• develop after P10
• at P13, optic nerve axons show almost no myelination in contrast to wild-type controls where about 50% of axons are myelinated
• severe loss of myelin basic protein (immunostaining) is observed in spinal cord at P13, but spinal root myelination (myelinated by Schwann cells) is normal
• essentially complete loss of myelination in CNS white matter tracts is observed at P13

vision/eye
• at P13, optic nerve axons show almost no myelination in contrast to wild-type controls where about 50% of axons are myelinated





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory