All Phenotypes Olig2<tm2(TVA,cre)Rth> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Olig2^{tm2(TVA,cre)Rth}
targeted mutation 2, David H Rowitch
MGI:3810299

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^{tm1(Smo/EYFP)Amc}/Gt(ROSA)26Sor^{tm1(Smo/EYFP)Amc} Olig2^{tm2(TVA,cre)Rth}/Olig2⁺	involves: 129 * 129X1/SvJ	MGI:3810318
cn2	Prrc2a^tm1Fcw/Prrc2a^tm1Fcw Olig2^{tm2(TVA,cre)Rth}/Olig2⁺	involves: 129 * C57BL/6	MGI:6724442
cn3	Mios^tm1Pfw/Mios^tm1Pfw Olig2^{tm2(TVA,cre)Rth}/Olig2⁺	involves: 129 * C57BL/6	MGI:6887924
cn4	Gt(ROSA)26Sor^{em2(Mios)Bcgen}/Gt(ROSA)26Sor⁺ Mios^tm1Pfw/Mios^tm1Pfw Olig2^{tm2(TVA,cre)Rth}/Olig2⁺	involves: 129 * C57BL/6	MGI:6887925
cn5	Cspg4^tm1Ychan/Cspg4^tm1Ychan Olig2^{tm2(TVA,cre)Rth}/Olig2⁺	involves: 129 * C57BL/6N	MGI:5427427
cn6	Gt(ROSA)26Sor^{tm1(Hoxa2)Fmr}/Gt(ROSA)26Sor⁺ Olig2^{tm2(TVA,cre)Rth}/Olig2⁺	involves: 129P2/OlaHsd	MGI:5470400
cn7	Myrf^tm1Barr/Myrf^tm1Barr Olig2^{tm2(TVA,cre)Rth}/Olig2⁺	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6	MGI:3852094

Allelic Composition	Gt(ROSA)26Sor^{tm1(Smo/EYFP)Amc}/Gt(ROSA)26Sor^{tm1(Smo/EYFP)Amc} Olig2^{tm2(TVA,cre)Rth}/Olig2⁺
Genetic Background	involves: 129 * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(Smo/EYFP)Amc} mutation (1 available); any Gt(ROSA)26Sor mutation (942 available)
Olig2^{tm2(TVA,cre)Rth} mutation (1 available); any Olig2 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:139574 )

• mice survive 33 days

neoplasm

increased medulloblastoma incidence ( J:139574 )

• mice develop focal medulloblastomas localized to the posterior-lateral lobes and have mean survival of 33 days

nervous system

increased medulloblastoma incidence ( J:139574 )

• mice develop focal medulloblastomas localized to the posterior-lateral lobes and have mean survival of 33 days

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
medulloblastoma		DOID:0050902	OMIM:155255	J:139574

Allelic Composition	Prrc2a^tm1Fcw/Prrc2a^tm1Fcw Olig2^{tm2(TVA,cre)Rth}/Olig2⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Olig2^{tm2(TVA,cre)Rth} mutation (1 available); any Olig2 mutation (46 available)
Prrc2a^tm1Fcw mutation (0 available); any Prrc2a mutation (62 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:301796 )

nervous system

nervous system phenotype ( J:301796 )

N	• mice exhibit normal ventral neuron numbers in the spinal cord

abnormal brain morphology ( J:301796 )

• however, neuron number is normal

decreased oligodendrocyte progenitor number ( J:301796 )

increased brain weight ( J:301796 )

enlarged lateral ventricles ( J:301796 )

abnormal corpus callosum morphology ( J:301796 )

• increased signal density on MRIs

• hypomyelination in the corpus callosum at 4 weeks of age and in adults

decreased oligodendrocyte number ( J:301796 )

dysmyelination ( J:301796 )

growth/size/body

decreased body weight ( J:301796 )

behavior/neurological

impaired spatial learning ( J:301796 )

impaired coordination ( J:301796 )

decreased grip strength ( J:301796 )

cellular

decreased oligodendrocyte progenitor number ( J:301796 )

Allelic Composition	Mios^tm1Pfw/Mios^tm1Pfw Olig2^{tm2(TVA,cre)Rth}/Olig2⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mios^tm1Pfw mutation (0 available); any Mios mutation (39 available)
Olig2^{tm2(TVA,cre)Rth} mutation (1 available); any Olig2 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:320720 )

N	• mice exhibit normal motor coordination and general activity levels/gross motor activity

nervous system

decreased oligodendrocyte number ( J:320720 )

• however, no increase in apoptosis was noted

abnormal oligodendrocyte physiology ( J:320720 )

• reduced proliferation of oligodendrocyte precursors due to delayed cell cycle exit

dysmyelination ( J:320720 )

• reduced number of myelinated optic nerves and in the corpus callosum

• reduced thickness of myelin wrap

• however, the distribution of axon diameters in the optic nerve is normal

Allelic Composition	Gt(ROSA)26Sor^{em2(Mios)Bcgen}/Gt(ROSA)26Sor⁺ Mios^tm1Pfw/Mios^tm1Pfw Olig2^{tm2(TVA,cre)Rth}/Olig2⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{em2(Mios)Bcgen} mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Mios^tm1Pfw mutation (0 available); any Mios mutation (39 available)
Olig2^{tm2(TVA,cre)Rth} mutation (1 available); any Olig2 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:320720 )

N	• mice exhibit normal oligodendrocyte myelination

Allelic Composition	Cspg4^tm1Ychan/Cspg4^tm1Ychan Olig2^{tm2(TVA,cre)Rth}/Olig2⁺
Genetic Background	involves: 129 * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cspg4^tm1Ychan mutation (0 available); any Cspg4 mutation (102 available)
Olig2^{tm2(TVA,cre)Rth} mutation (1 available); any Olig2 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

decreased epididymal fat pad weight ( J:184220 )

growth/size/body

decreased body weight ( J:184220 )

Allelic Composition	Gt(ROSA)26Sor^{tm1(Hoxa2)Fmr}/Gt(ROSA)26Sor⁺ Olig2^{tm2(TVA,cre)Rth}/Olig2⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(Hoxa2)Fmr} mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Olig2^{tm2(TVA,cre)Rth} mutation (1 available); any Olig2 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal brain development ( J:193058 )

• 2-fold decrease in ventral oligodendrogenesis in the prepontine (rhombomere 2- and 3-derived) and pontine (rhombomere 4-derived) territories compared with controls

• however, migration of oligodendrite progenitor cells is normal

decreased oligodendrocyte progenitor number ( J:193058 )

• decrease in ventral oligodendrogenesis in the prepontine (rhombomere 2- and 3-derived) and pontine (rhombomere 4-derived) territories at E13.5 due to reduced proliferation

• however, ventricular progenitors are recovered following additional cell cycle before differentiation

cellular

decreased oligodendrocyte progenitor number ( J:193058 )

• decrease in ventral oligodendrogenesis in the prepontine (rhombomere 2- and 3-derived) and pontine (rhombomere 4-derived) territories at E13.5 due to reduced proliferation

• however, ventricular progenitors are recovered following additional cell cycle before differentiation

Allelic Composition	Myrf^tm1Barr/Myrf^tm1Barr Olig2^{tm2(TVA,cre)Rth}/Olig2⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myrf^tm1Barr mutation (1 available); any Myrf mutation (100 available)
Olig2^{tm2(TVA,cre)Rth} mutation (1 available); any Olig2 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:150563 )

• mice die during third postnatal week

behavior/neurological

tremors ( J:150563 )

• severe tremors are observed around P11

ataxia ( J:150563 )

• observed around P11

seizures ( J:150563 )

• develop after P10

nervous system

nervous system phenotype ( J:150563 )

N	• gross CNS architecture is normal • motor neuron population in spinal cord is intact • peripheral nerves are fully myelinated

seizures ( J:150563 )

• develop after P10

abnormal optic nerve morphology ( J:150563 )

• at P13, optic nerve axons show almost no myelination in contrast to wild-type controls where about 50% of axons are myelinated

abnormal spinal cord morphology ( J:150563 )

• severe loss of myelin basic protein (immunostaining) is observed in spinal cord at P13, but spinal root myelination (myelinated by Schwann cells) is normal

abnormal myelination ( J:150563 )

• essentially complete loss of myelination in CNS white matter tracts is observed at P13

vision/eye

abnormal optic nerve morphology ( J:150563 )

• at P13, optic nerve axons show almost no myelination in contrast to wild-type controls where about 50% of axons are myelinated

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