Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tgfbr2tm1.2Hlm mutation
(0 available);
any
Tgfbr2 mutation
(39 available)
Tg(Foxp3-EGFP/cre)1cJbs mutation
(1 available)
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi mutation
(3 available)
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immune system
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N |
• mice do not develop diabetes
• normal T reg numbers in the spleen and pancreatic lymph nodes
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hematopoietic system
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lag3tm1Daav mutation
(0 available);
any
Lag3 mutation
(41 available)
Tg(Foxp3-EGFP/cre)1cJbs mutation
(1 available)
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immune system
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• reduction in the number of conventional effector T cells in islets is due to decreased CD8+ T cell proliferation
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• decrease in CD8+ T cell proliferation
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• CD4+Foxp3- T cells in islets show a reduction in IL-2 production
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• CD4+FoxP3- and CD8+ T cells in islets show reduced TNF-alpha production
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• females exhibit a delayed onset of autoimmune diabetes and decreased diabetes incidence (48% vs 84% in controls) by 30 weeks of age
• males are completely protected from developing autoimmune diabetes
• both males and females show a reduction in degree of insulitis at 10 weeks of age
• mice exhibit reduced lymphocyte infiltration into islets, with reduced numbers of CD4+FoxP3- and CD8+ T cells
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hematopoietic system
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• reduction in the number of conventional effector T cells in islets is due to decreased CD8+ T cell proliferation
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• decrease in CD8+ T cell proliferation
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lag3tm1Daav mutation
(0 available);
any
Lag3 mutation
(41 available)
Tg(Foxp3-EGFP/cre)1cJbs mutation
(1 available)
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immune system
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• females exhibit a diabetes incidence of 60% compared to 80-84% in controls
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Analysis Tools