About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gt(ROSA)26Sortm6(Map3k14*)Rsky
targeted mutation 6, Klaus Rajewsky
MGI:3809723
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Cd19tm1(cre)Cgn/Cd19+
Gt(ROSA)26Sortm6(Map3k14*)Rsky/Gt(ROSA)26Sortm6(Map3k14*)Rsky
involves: 129P2/OlaHsd * C57BL/6 MGI:3809749
cn2
Cd19tm1(cre)Cgn/Cd19+
Gt(ROSA)26Sortm6(Map3k14*)Rsky/Gt(ROSA)26Sortm6(Map3k14*)Rsky
Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass
involves: 129P2/OlaHsd * C57BL/6 MGI:3809751


Genotype
MGI:3809749
cn1
Allelic
Composition
Cd19tm1(cre)Cgn/Cd19+
Gt(ROSA)26Sortm6(Map3k14*)Rsky/Gt(ROSA)26Sortm6(Map3k14*)Rsky
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (8 available); any Cd19 mutation (15 available)
Gt(ROSA)26Sortm6(Map3k14*)Rsky mutation (1 available); any Gt(ROSA)26Sor mutation (523 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• in the peritoneal cavity
• the spleen contains 6-fold more AA4.1-B cells than in control mice due to enhanced survival
• however, B cell proliferation is normal
• lymphoid cells appear to spill over their normal confines into surrounding tissue unlike in wild-type mice

hematopoietic system
• in the peritoneal cavity
• the spleen contains 6-fold more AA4.1-B cells than in control mice due to enhanced survival
• however, B cell proliferation is normal




Genotype
MGI:3809751
cn2
Allelic
Composition
Cd19tm1(cre)Cgn/Cd19+
Gt(ROSA)26Sortm6(Map3k14*)Rsky/Gt(ROSA)26Sortm6(Map3k14*)Rsky
Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (8 available); any Cd19 mutation (15 available)
Gt(ROSA)26Sortm6(Map3k14*)Rsky mutation (1 available); any Gt(ROSA)26Sor mutation (523 available)
Tnfrsf13ctm1Mass mutation (1 available); any Tnfrsf13c mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
03/31/2020
MGI 6.15
The Jackson Laboratory