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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ano1tm1Bdh
targeted mutation 1, Brian D Harfe
MGI:3809591
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ano1tm1Bdh/Ano1tm1Bdh involves: 129S1/Sv MGI:3809595


Genotype
MGI:3809595
hm1
Allelic
Composition
Ano1tm1Bdh/Ano1tm1Bdh
Genetic
Background
involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ano1tm1Bdh mutation (0 available); any Ano1 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• over 90% of mice die within the first 9 days of life and all die prior to P30

respiratory system
• cartilage plates on the bronchi are abnormally patterned
• at E13.5, the circumference of the trachea is 40% greater than in wild-type mice
• at E14.5, the circumference of the trachea is 50% greater than in wild-type mice
• embryonic tracheal epithelium stratification is absent resulting in thinner epithelium than in wild-type mice
• development of smooth muscle cells is severely disrupted with globular distribution of cells rather than the filaments observed in wild-type mice
• the trachaelis muscle is absent from the dorsal aspect of the trachea
• mice lack ciliated epithelial cells in regions of evaginated tracheal epithelium
• however, the remainder of the tracheal epithelium is normally ciliated
• mice exhibit ventral gaps in the entire rostrocaudal axis of the tracheae that are observed as early as E15.5 in all mice
• trachea cartilage rings exhibit multiple disconnected cartilage condensations with intervening epithelial evaginations
• however, prechondrocytes are present at E12.5 and there is no change in proliferation or apoptosis rates in the trachea
• mice exhibit aerophagia

growth/size/body
• at P3, mice weight 65% of wild-type
• at P21, surviving mice weight less than half as mice as wild-type mice

homeostasis/metabolism
• mice have a cyanotic appearance

muscle
• development of smooth muscle cells is severely disrupted with globular distribution of cells rather than the filaments observed in wild-type mice
• the trachaelis muscle is absent from the dorsal aspect of the trachea

skeleton
• mice exhibit ventral gaps in the entire rostrocaudal axis of the tracheae that are observed as early as E15.5 in all mice
• trachea cartilage rings exhibit multiple disconnected cartilage condensations with intervening epithelial evaginations
• however, prechondrocytes are present at E12.5 and there is no change in proliferation or apoptosis rates in the trachea





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory