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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gapttm1.1Wz
targeted mutation 1.1, Weiguo Zhang
MGI:3809581
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Gapttm1.1Wz/Gapttm1.1Wz Not Specified MGI:3809586


Genotype
MGI:3809586
hm1
Allelic
Composition
Gapttm1.1Wz/Gapttm1.1Wz
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gapttm1.1Wz mutation (0 available); any Gapt mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• following stimulation with anti-CD40 antibodies, LPS or anti-IgM antibodies, mice exhibit increased B cell proliferation compared to in wild-type cells that is most significant at low levels of anti-IgM concentrations

immune system
N
• B and T cell development, humoral response and BCR-mediated signaling are normal
• following stimulation with anti-CD40 antibodies, LPS or anti-IgM antibodies, mice exhibit increased B cell proliferation compared to in wild-type cells that is most significant at low levels of anti-IgM concentrations

hematopoietic system
• following stimulation with anti-CD40 antibodies, LPS or anti-IgM antibodies, mice exhibit increased B cell proliferation compared to in wild-type cells that is most significant at low levels of anti-IgM concentrations





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory