Analysis Tools
normal phenotype
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• mice are viable and fertile; used for cre reporter expression analysis
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Allele Symbol Allele Name Allele ID |
Gt(ROSA)26Sortm9(CAG-tdTomato)Hze targeted mutation 9, Hongkui Zeng MGI:3809523 |
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| Summary |
13 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice are viable and fertile; used for cre reporter expression analysis
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 2-fold increase in the number of oligodendroglial cells in the ventral brainstem at P7 and P21
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• reduced cellularity in tamoxifen-treated mice from P4
• however, mice recover one month after the last tamoxifen application
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit a similar overall pancreatic tumor burden as KPCT (Krastm4Tyj/Kras+ Trp53tm2Tyj/Trp53+ Tg(Pdx1-cre)6Tuv/0 Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+) mice
• pancreas contains PanINs and adenocarcinoma that are similar to pancreatic ductal adenocarcinoma (PDAC) in KPCT mice
• only 3 of 14 mice develop metastases, with only half of mice showing peritoneal disseminated tumor cells
• cancer cells exhibit a higher mitotic index than KPCT mice
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• pancreas contains PanINs and adenocarcinoma that are similar to PDAC in KPCT mice
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• mice exhibit a shorter survival than KPCT mice
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• mice exhibit a similar overall pancreatic tumor burden as KPCT (Krastm4Tyj/Kras+ Trp53tm2Tyj/Trp53+ Tg(Pdx1-cre)6Tuv/0 Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+) mice
• pancreas contains PanINs and adenocarcinoma that are similar to pancreatic ductal adenocarcinoma (PDAC) in KPCT mice
• only 3 of 14 mice develop metastases, with only half of mice showing peritoneal disseminated tumor cells
• cancer cells exhibit a higher mitotic index than KPCT mice
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• pancreas contains PanINs and adenocarcinoma that are similar to PDAC in KPCT mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• pancreas contains PanINs and adenocarcinoma
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• pancreas contains PanINs and adenocarcinoma
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• pancreas contains PanINs and adenocarcinoma
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• pancreas contains PanINs and adenocarcinoma
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• most mice develop metastases which are numerous and widespread in many different sites, including the lymph nodes, diaphragm, lungs, and liver
• all mice exhibit peritoneal disseminated tumor cells
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• starburst amacrine cells in flat mount retinas show excess and aberrant light-evoked inhibitory postsynaptic currents
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• frequent olfactory receptor switching at 6 weeks
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• frequent olfactory receptor switching at 6 weeks
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• frequent olfactory receptor switching at 6 weeks
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• frequent olfactory receptor switching at 6 weeks
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• frequent olfactory receptor switching at 6 weeks
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• adult injection of cre-expressing virus produces an increase in intrinsic excitability of dentate gyrus neurons compared with control mice
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• mice injected with a cre-expressing virus exhibit an increase in dentate gyrus neuron AMPA/NMDA ratio compared with control mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice develop pancreatic ductal adenocarcinoma (PDAC)
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• mice develop pancreatic ductal adenocarcinoma (PDAC)
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• GFP+ PDAC cells form tumors form more metastases than GFP- PDAC cells when transplanted into recipient mice
• the highly metastatic PDAC subpopulation is enriched for hypoxia-induced genes
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| pancreatic ductal adenocarcinoma | DOID:3498 | J:245611 | ||
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 10 days after sparse injection with cre-expressing virus, mice exhibit decreased spine density, spine head width and spine neck length compared with control mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• with tamoxifen administration to dams from E8.5 to 14.5, embryonic lungs display abnormal shape and simplified branching (reduced number of terminal buds in accessory lobe as example)
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• with tamoxifen administration to dams from E8.5 to 14.5, webbed digits are observed at level of forelimbs in embryos
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• with tamoxifen administration to dams from E8.5 to 14.5, cecum length is decreased in embryos relative to controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• on a standard chow diet, 9 week-old mice given an injection of diphtheria toxin, with a second injection 1 week later, to ablate oxytocin-expressing neurons (lesioned mice), showed comparable body weight through 20 weeks of age
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• when 9 week-old mice were given an injection of diphtheria toxin, with a second injection 1 week later, and maintained on a high fat diet following treatment, males displayed comparable body weight to controls up to 14 weeks of age, then develop higher body weight relative to controls at 22 weeks of age; in contrast, females show no difference in body weight compared to controls up to 22 weeks of age
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• diphtheria toxin-treated males (lesioned) show significantly higher fat mass; lean masses are comparable
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| N |
• average daily food consumption measured over one week in control and lesioned (diphtheria toxin-treated) males are similar on normal chow and high fat diets
• treatment of control and lesioned mice with MTII (melanocortin receptor agonist) reduced feeding in the dark to similar degrees in both cohorts
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• after overnight fasting, leptin administration caused a 25% reduction in 2-hour feeding in lesioned mice and had no significant effect on 4- and 24-hour feeding whereas control mice treated with leptin showed a 25% decrease in 2- and 4-hour feeding and blunted 24-hour feeding by 20%
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• when 9 week-old mice were given an injection of diphtheria toxin, with a second injection 1 week later, and maintained on a high fat diet following treatment, males displayed comparable body weight to controls up to 14 weeks of age, then develop higher body weight relative to controls at 22 weeks of age; in contrast, females show no difference in body weight compared to controls up to 22 weeks of age
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• lesioned mice on a high fat diet show lower oxygen consumption during a 2 day period of high fat diet, particularly during the dark cycle, compared to controls; during a 2 day period on normal chow diet, oxygen consumption is comparable between the two genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at E18.5, cortices show an apical shift in the expression domain of Cux2, a marker of intermediate progenitors that give rise to upper layer (UL) 2/3 cortical projection neurons (CPNs)
• however, TdTomato levels are largely normal at E14.5, E16.5 and E18.5
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• in culture, primary upper layer CPNs show a progressive reduction in neurite outgrowth and branching complexity
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/09/2024 MGI 6.23 |
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