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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Igh-Jtm3(3H9-VDJ*)Mwg
targeted mutation 3, Martin Weigert
MGI:3808989
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Igh-Jtm3(3H9-VDJ*)Mwg/Igh-Jtm3(3H9-VDJ*)Mwg involves: 129P2/OlaHsd * BALB/c * C57BL/6 MGI:3809012


Genotype
MGI:3809012
hm1
Allelic
Composition
Igh-Jtm3(3H9-VDJ*)Mwg/Igh-Jtm3(3H9-VDJ*)Mwg
Genetic
Background
involves: 129P2/OlaHsd * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm3(3H9-VDJ*)Mwg mutation (0 available); any Igh-J mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• the heavy chain encoded by the knocked-in allele is paired with a very limited repertoire of kappa light chains with the majority of these being from the Vkappa38c family
• many of these kappa light chains disrupt the intrinsic DNA-binding ability of the heavy chain so that relatively few B cells outside the bone marrow produce antibodies that bind double-stranded DNA
• sequence analysis reveals most B cells have undergone receptor rearrangement multiple times with a bias towards Jkappa5 occurring, deletion of Ckappa often observed, and a high frequency of deletional and inverted rearrangements
• B cell hybridomas developed from these mice produce antibodies that bind dsDNA

hematopoietic system
• the heavy chain encoded by the knocked-in allele is paired with a very limited repertoire of kappa light chains with the majority of these being from the Vkappa38c family
• many of these kappa light chains disrupt the intrinsic DNA-binding ability of the heavy chain so that relatively few B cells outside the bone marrow produce antibodies that bind double-stranded DNA
• sequence analysis reveals most B cells have undergone receptor rearrangement multiple times with a bias towards Jkappa5 occurring, deletion of Ckappa often observed, and a high frequency of deletional and inverted rearrangements





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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory