• in incisors ameloblasts appear to lose contact with their subadjacent matrix and their cytoplasm becomes atypically eosinophilic (J:157947)

• in the transition and maturation zones cells become highly disorganized with the ameloblasts losing their characteristic columnar morphology and forming a multi-cellular mass (J:157947)

• severely hypoplastic (J:157947)

• large areas of enamel are missing (J:157947)

• occasional small blister like structures of variable size are apparent from the late secretory stage onwards (J:157947)

• within the blister like structures aberrant matrix is present with areas appearing less eosinophilic than the original enamel matrix (J:157947)

• decrease in enamel mineral content (J:157947)

• but no defect in dentine mineral levels (J:157947)

• incisors display patchy regions of roughened, chalky white enamel (J:157947)

• patchy regions of chalky white enamel (J:157947)

• the upper and lower incisors are shortened (J:157947)

• incisors display patchy regions of roughened, chalky white enamel (J:157947)

• by SEM the prismatic structure is less highly ordered with greater inter-prismatic spacing (J:157947)

• shortened with irregular incisal edge (J:157947)

• rough tooth surface (J:133634)

• mandible is enlarged, eroded and discolored, containing a large mass of soft tissue (J:157947)

• at the ameloblast enamel interface the regular pattern of Tomes' process insertions is absent and instead there is a disorganized vesicular pattern (J:157947)

• in both incisors and molars, ameloblasts appear to lose contact with their sub-adjacent matrix and their cytoplasm becomes atypically eosinophilic (J:157947)

• in the transition and maturation zones cells become highly disorganized with the ameloblasts losing their characteristic columnar morphology and forming a multi cellular (J:157947)

• much of debris of the multi cellular masses is either TUNEL- or activated caspase-3-positive (J:157947)

• eosinophilic structures are visible throughout the cell and appear to be vesicular in nature with accumulations of both amelogenin and ameloblastin in affected cells (J:157947)

• contact of the ameloblasts with the enamel matrix is lost leading to the formation of out-pocketings containing eosinophilic material (J:157947)

• the mineralizing enamel distal to the white opaque zone is irregular and discolored with ridges perpendicular to the long axis of the incisor (J:157947)

• entire enamel surface is roughened opaque and chalky white (J:157947)

• frequently have an irregular incisal edge (J:157947)

• opaque and chalky white enamel (J:157947)

• the upper and lower incisors are shortened (J:157947)

• opaque and roughened, with abrasion of the cusps (J:157947)

• the upper and lower incisors are uneven and present a chalky white, opaque appearance with roughened/pitted surfaces (J:157947)

• large areas of the teeth lack enamel (J:157947)

• by SEM enamel is severely dysplastic non-prismatic 'enamel' with a smooth glass-like appearance and no evidence of clear prismatic structure (J:157947)

• shortened with irregular incisal edge (J:157947)

• mandible is enlarged, eroded and discolored, containing a large mass of soft tissue (J:157947)