About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mib1tm2Kong
targeted mutation 1, Young-Yun Kong
MGI:3804448
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Mib1tm2Kong/Mib1tm2Kong
Tg(Tek-cre)12Flv/0
involves: 129P2/OlaHsd * C3H * C57BL/6 MGI:3804815
cn2
Mib1tm2Kong/Mib1tm2Kong
Tg(Msx2-cre)5Rem/0
involves: 129P2/OlaHsd * C57BL/6 MGI:3804816
cn3
Mib1em1Jlp/Mib1tm2Kong
Tg(Tnnt2-cre)5Blh/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:7544909
cn4
Mib1tm2Kong/Mib1tm2Kong
Tg(GFAP-cre)25Mes/0
involves: 129P2/OlaHsd * C57BL/6 * FVB/N MGI:3804817
cn5
Mib1tm2Kong/Mib1tm2Kong
Foxa2tm3.1(icre)Heli/Foxa2+
involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:5428765


Genotype
MGI:3804815
cn1
Allelic
Composition
Mib1tm2Kong/Mib1tm2Kong
Tg(Tek-cre)12Flv/0
Genetic
Background
involves: 129P2/OlaHsd * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mib1tm2Kong mutation (0 available); any Mib1 mutation (55 available)
Tg(Tek-cre)12Flv mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

embryo
• at E9.5 and E10.5
• at E9.5 and E10.5
• at E9.5 and E10.5, mice exhibit defects characteristic of vascular remodeling

cardiovascular system
N
• despite defects in vascular remodeling, vasculogenesis is normal
• the dorsal aorta is narrower than in wild-type mice and arterial specification is abnormal
• capillary networks are less extensive and more primitive than in wild-type mice
• at E9.5 and E10.5
• at E9.5 and E10.5

hematopoietic system
• cultures of para-aortic splanchnopleura produce fewer colony forming cells when cultured alone or on OP9 cells compared to cultured wild-type cells

growth/size/body
• at E9.5 and E10.5

homeostasis/metabolism
• at E9.5 and E10.5

cellular
• capillary networks are less extensive and more primitive than in wild-type mice




Genotype
MGI:3804816
cn2
Allelic
Composition
Mib1tm2Kong/Mib1tm2Kong
Tg(Msx2-cre)5Rem/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mib1tm2Kong mutation (0 available); any Mib1 mutation (55 available)
Tg(Msx2-cre)5Rem mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• digits 2 through 4 are fused in adulthood
• mice exhibit fusion of soft tissues and nails of digits 2 and 3
• at E13.5, the interdigit space between digits 2 and 3 is narrower than in wild-type mice
• at E15.5, interdigit separation is absent due to a decrease in interdigital cell death

growth/size/body
• at P28, mice exhibit epidermal cysts below the interfollicular epidermis that are filled with cornified materials

skeleton
• digits 2 through 4 are fused in adulthood
• mice exhibit fusion of soft tissues and nails of digits 2 and 3

integument
• mice are bald at 4 weeks of age
• mice begin to lose their hair along the dorsal midline and bald at 4 weeks of age
• at 28 days, hair follicles are barely detected in the back skin
• at P28, the epidermal cell layer has numerous squame
• at P28, mice exhibit epidermal cysts below the interfollicular epidermis that are filled with cornified materials
• at P28

cellular
• at E15.5, interdigit separation is absent due to a decrease in interdigital cell death




Genotype
MGI:7544909
cn3
Allelic
Composition
Mib1em1Jlp/Mib1tm2Kong
Tg(Tnnt2-cre)5Blh/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mib1em1Jlp mutation (0 available); any Mib1 mutation (55 available)
Mib1tm2Kong mutation (0 available); any Mib1 mutation (55 available)
Tg(Tnnt2-cre)5Blh mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• noncompacted trabeculae in ventricular myocardium in adults
• left ventricular compact layer 45% thinner in E16.5 embryos
• reduced compact-to-trabecular myocardium ratio in E16.5 embryos
• various conotruncal defects in E16.5 embryos
• dysplasia in adults
• in E16.5 embryos
• myocardial fibrosis in septum and around coronary vessels in adults
• reduced fractional shortening and ejection fraction in adults

mortality/aging

muscle
• noncompacted trabeculae in ventricular myocardium in adults
• left ventricular compact layer 45% thinner in E16.5 embryos
• reduced compact-to-trabecular myocardium ratio in E16.5 embryos
• reduced fractional shortening and ejection fraction in adults




Genotype
MGI:3804817
cn4
Allelic
Composition
Mib1tm2Kong/Mib1tm2Kong
Tg(GFAP-cre)25Mes/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mib1tm2Kong mutation (0 available); any Mib1 mutation (55 available)
Tg(GFAP-cre)25Mes mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die at 2 to 4 months of age

nervous system
• mice exhibit a delay in the migration of cells from the external granule layer to the internal granule layer
• at P9, the external granule cell layer contains more granule cells than in wild-type mice
• unlike in wild-type mice, granule cells are maintained at P17 but migrate to the internal granule cell layer by P21
• however, cell proliferation within the external granule layer is normal
• at P15, Bergmann glial cell processes are severely disorganized

growth/size/body

cellular
• mice exhibit a delay in the migration of cells from the external granule layer to the internal granule layer




Genotype
MGI:5428765
cn5
Allelic
Composition
Mib1tm2Kong/Mib1tm2Kong
Foxa2tm3.1(icre)Heli/Foxa2+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxa2tm3.1(icre)Heli mutation (0 available); any Foxa2 mutation (26 available)
Mib1tm2Kong mutation (0 available); any Mib1 mutation (55 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• loss of DBA+ve (D. biflorus agglutinin) duct structures is observed by E18.5
• at E9.5, an excess of Neurog3+ve cells is found in the dorsal pancreatic bud; near complete conversion of dorsal bud cells to glucagon+ve cells occurs by E10.5
• at E10.5, dorsal pancreas is absent, but ventral pancreatic anlage forms normally
• proximal-distal patterning is altered in the embryonic pancreas; at E15.5, Nkx6-1+ve, Ptf1a-ve cells are absent from the proximal domain while Hnf1b and DBA+ve cells are also lost, with a concurrent increase in Nkx6-1-ve, Ptf1a+ve cells as well as Cpa+ve and amylase +ve cells
• at E12.5, Nkx6-1+ve Ptf1a-ve are present, but reduced in numbers by 50% compared to controls along with a corresponding increase in Nkx6-1-ve Ptf1a+ve cells
• insulin-producing cells are absent by E18.5

digestive/alimentary system
• loss of DBA+ve (D. biflorus agglutinin) duct structures is observed by E18.5

cellular
• insulin-producing cells are absent by E18.5





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory