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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rdh1tm1.1Jln
targeted mutation 1.1, Joseph Napoli
MGI:3804065
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Rdh1tm1.1Jln/Rdh1tm1.1Jln B6.129P2-Rdh1tm1.1Jln MGI:3804208


Genotype
MGI:3804208
hm1
Allelic
Composition
Rdh1tm1.1Jln/Rdh1tm1.1Jln
Genetic
Background
B6.129P2-Rdh1tm1.1Jln
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rdh1tm1.1Jln mutation (1 available); any Rdh1 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• 15% less water and 28% less ash than in wild-type mice after dehydration and extraction
• despite same food intake, mice fed a low or deficient vitamin A diet weigh more than similarly treated wild-type mice
• male mice fed a low or deficient vitamin A diet are longer than similarly treated wild-type mice
• 25% increase compared to in wild-type mice
• 58% increase compared to in wild-type mice

adipose tissue
• epididymal, retroperitonal and brown fat pads weight 1.8-fold more than in wild-type mice while mesentery, femoral and inguinal fat pads weight 3.7-, 2.7- and 2.8-fold, respectively, more than in wild-type mice and are disproportional large relative to body weight
• despite same food intake, mice have 59% more fat and a 39% greater adiposity index compared to wild-type mice after dehydration and extractions

homeostasis/metabolism
• when fed a high or marginal vitamin A diet, mice exhibit a 2-fold increase in liver retinol levels compared to similarly treated wild-type mice
• when fed a marginal vitamin A diet, mice exhibit a 40% increase in kidney retinol levels

liver/biliary system
• 58% increase compared to in wild-type mice

renal/urinary system
• 25% increase compared to in wild-type mice

embryo
N
• regardless of vitamin A content in maternal diet, mice develop normally





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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory