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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		F3tm1Nmk
targeted mutation 1, Nigel Mackman
MGI:3803978
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		F3tm1Nmk/F3tm1Nmk
Myl2tm1(cre)Krc/? 		involves: 129S4/SvJae * 129S6/SvEvTac MGI:3826855
cn2
 		F3tm1Nmk/F3tm1Nmk
Myl2tm1(cre)Krc/?
Tg(Myh6-F3)4Nmk/? 		involves: 129S4/SvJae * 129S6/SvEvTac * BALB/c * C57BL/6 MGI:3826858


Genotype
MGI:3826855
cn1
Allelic
Composition		 F3tm1Nmk/F3tm1Nmk
Myl2tm1(cre)Krc/?
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F3tm1Nmk mutation (1 available); any F3 mutation (24 available)
Myl2tm1(cre)Krc mutation (2 available); any Myl2 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiac fibrosis ( J:137921 )
• normal hearts at 6 months
• hemosiderin deposition and fibrosis in 3 of 12 hearts examined at 9 months
• isoproterenol treatment of 3 month old mice also results in hemosiderin deposition and fibrosis




Genotype
MGI:3826858
cn2
Allelic
Composition		 F3tm1Nmk/F3tm1Nmk
Myl2tm1(cre)Krc/?
Tg(Myh6-F3)4Nmk/?
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F3tm1Nmk mutation (1 available); any F3 mutation (24 available)
Myl2tm1(cre)Krc mutation (2 available); any Myl2 mutation (22 available)
Tg(Myh6-F3)4Nmk mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:137921 )
N
• mice are normal to 6 months of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory