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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Irs1tm1Mfw
targeted mutation 1, Morris F White
MGI:3803962
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Irs1tm1Mfw/Irs1tm1Mfw
Irs2tm2Mfw/Irs2tm2Mfw
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA MGI:3805306
cn2
 		Irs1tm1Mfw/Irs1tm1Mfw
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA MGI:3805308
cn3
 		Foxo1tm1Rdp/Foxo1tm1Rdp
Irs1tm1Mfw/Irs1tm1Mfw
Irs2tm2Mfw/Irs2tm2Mfw
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA * FVB MGI:3805304
cn4
 		Irs1tm1Mfw/Irs1+
Irs2tm2Mfw/Irs2tm2Mfw
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA * FVB/N MGI:4430357
cn5
 		Irs1tm1Mfw/Irs1tm2.1Mfw
Irs2tm2Mfw/Irs2tm2Mfw
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA * FVB/N MGI:4430356


Genotype
MGI:3805306
cn1
Allelic
Composition		 Irs1tm1Mfw/Irs1tm1Mfw
Irs2tm2Mfw/Irs2tm2Mfw
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irs1tm1Mfw mutation (0 available); any Irs1 mutation (51 available)
Irs2tm2Mfw mutation (0 available); any Irs2 mutation (35 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating glucose level ( J:137845 )
• fasting and postprandial
hyperglycemia ( J:137845 )
• by 5 weeks of age
increased circulating insulin level ( J:137845 )
• fasting and postprandial
decreased circulating triglyceride level ( J:137845 )
• at 3 months of age, triglyceride secretion is decreased 60% compared to in wild-type mice

liver/biliary system

immune system

growth/size/body
decreased body size ( J:137845 )




Genotype
MGI:3805308
cn2
Allelic
Composition		 Irs1tm1Mfw/Irs1tm1Mfw
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irs1tm1Mfw mutation (0 available); any Irs1 mutation (51 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism




Genotype
MGI:3805304
cn3
Allelic
Composition		 Foxo1tm1Rdp/Foxo1tm1Rdp
Irs1tm1Mfw/Irs1tm1Mfw
Irs2tm2Mfw/Irs2tm2Mfw
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1tm1Rdp mutation (2 available); any Foxo1 mutation (31 available)
Irs1tm1Mfw mutation (0 available); any Irs1 mutation (51 available)
Irs2tm2Mfw mutation (0 available); any Irs2 mutation (35 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
homeostasis/metabolism phenotype ( J:137845 )
N
• unlike in Irs1 and Irs2 double null mice, fasting glucose, insulin, and adiponectin levels, insulin resistance, fed glucose levels, hepatic glycogen levels, and glucose tolerance are normal
decreased circulating HDL cholesterol level ( J:137845 )
• mice exhibit a partial recovery of plasma HDL cholesterol levels compared to in Irs1 and Irs2 double knockout mice
abnormal triglyceride level ( J:137845 )
• triglyceride secretion is decreased compared to in wild-type mice but increased compared to in Irs1 and Irs2 double knockout mice




Genotype
MGI:4430357
cn4
Allelic
Composition		 Irs1tm1Mfw/Irs1+
Irs2tm2Mfw/Irs2tm2Mfw
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irs1tm1Mfw mutation (0 available); any Irs1 mutation (51 available)
Irs2tm2Mfw mutation (0 available); any Irs2 mutation (35 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
impaired glucose tolerance ( J:156999 )
• significantly glucose intolerant




Genotype
MGI:4430356
cn5
Allelic
Composition		 Irs1tm1Mfw/Irs1tm2.1Mfw
Irs2tm2Mfw/Irs2tm2Mfw
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irs1tm1Mfw mutation (0 available); any Irs1 mutation (51 available)
Irs1tm2.1Mfw mutation (0 available); any Irs1 mutation (51 available)
Irs2tm2Mfw mutation (0 available); any Irs2 mutation (35 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating insulin level ( J:156999 )
• fasting and fed insulin concentrations are elevated
impaired glucose tolerance ( J:156999 )
• severe glucose intolerance
insulin resistance ( J:156999 )
• significant insulin resistance




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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory