About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Itgb4tm1.1Mfel
targeted mutation 1.1, Maria Laura Feltri
MGI:3803794
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Itgb4tm1.1Mfel/Itgb4tm1.1Mfel involves: 129S2/SvPas * C57BL/6 MGI:3804178
cn2
Itgb4tm1Mfel/Itgb4tm1.1Mfel
Tg(Mpz-cre)26Mes/0
involves: 129S2/SvPas * C57BL/6 * FVB/N MGI:3804180


Genotype
MGI:3804178
hm1
Allelic
Composition
Itgb4tm1.1Mfel/Itgb4tm1.1Mfel
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb4tm1.1Mfel mutation (0 available); any Itgb4 mutation (81 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• blisters formed by dermal-epidermal layer detachment




Genotype
MGI:3804180
cn2
Allelic
Composition
Itgb4tm1Mfel/Itgb4tm1.1Mfel
Tg(Mpz-cre)26Mes/0
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb4tm1.1Mfel mutation (0 available); any Itgb4 mutation (81 available)
Itgb4tm1Mfel mutation (0 available); any Itgb4 mutation (81 available)
Tg(Mpz-cre)26Mes mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• progressive increase in the number of myelin infoldings in the sciatic nerve, digital nerve, and anterior roots after 12 months of age

behavior/neurological
N
• despite loss of expression in Schwann cells, no tremors, gait abnormalities, or motor skill impairments are detected





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/06/2021
MGI 6.16
The Jackson Laboratory