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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ranbp2tm1.1Jvd
targeted mutation 1.1, Jan M A van Deursen
MGI:3800899
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ranbp2tm1.1Jvd/Ranbp2tm1.1Jvd involves: 129/Sv * C57BL/6 MGI:3802797
ht2
Ranbp2tm1.1Jvd/Ranbp2+ involves: 129/Sv * C57BL/6 MGI:3802799
ht3
Ranbp2tm1Jvd/Ranbp2tm1.1Jvd involves: 129/Sv * C57BL/6 MGI:3802800


Genotype
MGI:3802797
hm1
Allelic
Composition
Ranbp2tm1.1Jvd/Ranbp2tm1.1Jvd
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ranbp2tm1.1Jvd mutation (0 available); any Ranbp2 mutation (63 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:3802799
ht2
Allelic
Composition
Ranbp2tm1.1Jvd/Ranbp2+
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ranbp2tm1.1Jvd mutation (0 available); any Ranbp2 mutation (63 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• in about 1% of splenocytes
• also range of aneuploidy broadened




Genotype
MGI:3802800
ht3
Allelic
Composition
Ranbp2tm1Jvd/Ranbp2tm1.1Jvd
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ranbp2tm1.1Jvd mutation (0 available); any Ranbp2 mutation (63 available)
Ranbp2tm1Jvd mutation (0 available); any Ranbp2 mutation (63 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
liver/biliary system

respiratory system

cellular
• in about 15% of splenocytes
• also range of aneuploidy broadened
• 9% of splenocytes fail to progress from metaphase to anaphase
• in cells in which mitosis proceeds, 30% form chromatin bridges
• small number of cells with more than two bridges between chromosomes
• bridges resolve during telophase or cytokinesis
• no evidence for increased chromosome breakage or end-end fusions

neoplasm
• increased incidence of spontaneous tumor development
• dramatic increase in skin tumors within 5 months of treatment with DMBA
• 100% of mice with lung tumors within 5 months of treatment with DMBA
• elevated tumor burden (14/mouse) in mice treated with DMBA
• shorter latency for spontaneous tumor development

homeostasis/metabolism
• dramatic increase in skin tumors within 5 months of treatment with DMBA
• 100% of mice with lung tumors within 5 months of treatment with DMBA
• elevated tumor burden (14/mouse) in mice treated with DMBA





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory