Phenotypes associated with this allele
nervous system
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• frequent deposits are observed in hilus of dentate gyrus
• almost no thioflavin-S positive fibrillar Abeta plaques are observed in cortex and hippocampus
• mice show 2- to 3-fold less Abeta in the brain relative to Tg(APPV717F)109Ili, Apoe-wild-type controls
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APPV717F)109Ili mutation
(0 available)
Tg(Prnp-Abca1)EHol mutation
(1 available)
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nervous system
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• at 12 months, rare amyloid beta (Abeta) deposits are observed in the cortex, with occasional deposits in the molecular layer of hippocampus and frequent Abeta deposits in the hilus of the dentate gyrus; mice show 3-fold less Abeta in the brain relative to Tg(APPV717F)109Ili, Abca1-wild-type controls
• fibrillar Abeta plaques are frequently observed in cortex and hippocampus
• Abeta deposits are almost all diffuse, with little true amyloid
• very few clusters of reactive microglia are seen in brain
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Prnp-Abca1)EHol mutation
(1 available)
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reproductive system
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• 3-fold increased numbers of apoptotic cells in testes relative to controls
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• tubules display atrophy with marked degenerative changes such as large increase in multinucleated giant cells and cells with condensed nuclei
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• testes exhibit maturation arrest due to absence of mature products of spermatogenesis
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• 50% reduction in testes mass relative to wild-type controls
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• elongated spermatids and spermatozoa are absent in testes of mutant males
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nervous system
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• in 12-month old mice have frequent amyloid beta (Abeta) deposits in cortex and hippocampus including molecular layer of hippocampus
• almost no deposits are observed in hilus of dentate gyrus of hippocampus
• thioflavin-S positive fibrillar Abeta plaques are frequently observed in cortex and hippocampus at 12 months
• thioflavin-S positive plaques are associated with reactive microglia
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• Apoe-containing lipoprotein particles secreted by astrocytes contain more lipid than those secreted by non-transgenic controls; lipoprotein fractions contain a greater ratio of cholesterol to Apoe
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homeostasis/metabolism
endocrine/exocrine glands
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• 3-fold increased numbers of apoptotic cells in testes relative to controls
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• tubules display atrophy with marked degenerative changes such as large increase in multinucleated giant cells and cells with condensed nuclei
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• testes exhibit maturation arrest due to absence of mature products of spermatogenesis
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• 50% reduction in testes mass relative to wild-type controls
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cellular
Analysis Tools